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ISSN: 0974-8369

Biology and Medicine
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Research Article

Systemic Inflammation Mediates the Effects of Endotoxemia in the Mechanisms of Heat Stroke

Chin Leong Lim1 and Katsuhiko Suzuki2*

1Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, Singapore

2Faculty of Sport Sciences, Waseda University, Mikajima, Tokorozawa, Saitama, Japan

*Corresponding Author:
Katsuhiko Suzuki, MD, PhD
Faculty of Sport Sciences, Waseda University
2-579-15 Mikajima, Tokorozawa
Saitama 359-1192, Japan
Tel: +81-4-2947-6898
E-mail: [email protected]

Received Date: November 30, 2016; Accepted Date: December 24, 2016; Published Date: December 31, 2016

Citation: Lim CL, Suzuki K (2016) Systemic Inflammation Mediates the Effects of Endotoxemia in the Mechanisms of Heat Stroke. Biol Med (Aligarh) 9: 376. doi:10.4172/0974-8369.1000376

Copyright: © 2016 Lim CL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

Abstract

Heat stroke is triggered by heat, but is driven by endotoxemia and the downstream effects of systemic inflammation, acute phase response and the pyrogenic response. Whereas heat stroke and its related fatality commonly occur at core temperature (Tc) >40°C, healthy individuals have tolerated Tc 40°C-42°C without symptoms of heat stroke, suggesting that besides hyperthermia, there are other factors that can also cause heat stroke. The “Dual-pathway model (DPM)” suggests that heat stroke is triggered by the endotoxemia pathway at Tc up to ~ 42°C and independently, by heat toxicity at Tc >42°C. The second pathway in the DPM is based on evidence showing that cytoskeletal structures start to disintegrate at ambient temperature >41.5°C. Since most exertional stroke cases occur at Tc <42°C, the endotoxemia pathway, and not heat, might be the primary cause of heat stroke in the active population. Current evidence suggests that exercising under a poor state of health and a compromised immune system may also cause heat stroke, independent from the effects of hyperthermia. Strategies to prevent heat stroke should put equal emphasis on maintaining a good state of health and immune function. The current practice of focusing primarily on heat strain and hydration to prevent heat stroke may not have comprehensively addressed the pathophysiology of heat stroke and may explain why heat stroke continues to occur after more than 2000 years.

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