The Current Utilization of Cognitive Tests in the Research of Radiation-Induced Cognitive Dysfunction in Rodent Models
Xiao-Yang Li, Lie-Song Chen, Li-Yuan Zhang, and Ye Tian*
Department of Radiotherapy and Oncology, The Second Affiliated Hospital of Soochow University, Institute of Radiotherapy and Oncology, Soochow University, Suzhou, Jiangsu, China
- *Corresponding Author:
- Ye Tian
Department of Radiotherapy and Oncology
The Second Affiliated Hospital of Soochow University
Suzhou Key Laboratory for Radiation Oncology, Suzhou, China
E-mail: [email protected]
Received Date: May 17, 2016; Accepted Date: June 02, 2017; Published Date: June 09, 2017
Citation: Li X, Chen L, Zhang L, Tian Y (2017) The Current Utilization of Cognitive Tests in the Research of Radiation-Induced Cognitive Dysfunction in Rodent Models. Brain Disord Ther 6:235. doi: 10.4172/2168-975X.1000235
Copyright: © 2017 Li X, et al.. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Whole brain irradiation using low LET rays has remained the mainstay to treat some primary and metastatic brain tumors. Radiation-induced cognitive dysfunction is a progressive and irreversible late side effect after whole brain irradiation and inevitably decreases the quality of life of cancer survivors. To address this negative issue, many studies have been performed to explore the mechanisms of radiation-induced cognitive dysfunction and to develop efficacious preventive and treating measures. The prerequisite and foundation of implementing a persuasive and profound study to investigate radiation-induced cognitive dysfunction is the utilization of widely acknowledged animal models and universally applied cognitive tests. In this review, articles studying radiation-induced cognitive dysfunction from 2011 to 2016 were collected. The establishment of animal models and detailed utilization of cognitive tests were analyzed and summarized. This review summarized the general range of irradiation doses and time intervals utilized and the effects of these two factors on the results of cognitive tests.