The Edible Adlay Seed Oil Containing Cinnamaldehyde and Gingerol Prevents DMBA/TPA-Induced Skin Carcinogenesis by Cooperative Ablation of Lipid Rafts
- *Corresponding Author:
- Gangjun Du
Department of Oncology
The First Hospital Affiliated to Henan University
Kaifeng, Henan Province 475001, PR China
E-mail: [email protected]/[email protected]
Received Date: June 12, 2017; Accepted Date: August 02, 2017; Published Date: August 07, 2017
Citation: Zheng Y, Geng S, Meng M, Du Z, Yao J, et al. (2017) The Edible Adlay Seed Oil Containing Cinnamaldehyde and Gingerol Prevents DMBA/TPA-Induced Skin Carcinogenesis by Cooperative Ablation of Lipid Rafts. J Carcinogene Mutagene 8:302. doi: 10.4172/2157-2518.1000302
Copyright: © 2017 Zheng Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It is known that food intake was associated with decreased risk of cancer, we prepared a compounded adlay seed oil (C-ASO) containing 0.5% cinnamaldehyde and 1% 6-gingerol and evaluated the preventive effects of the oral C-ASO on DMBA/TPA-induced skin carcinogenesis. In contrast to untreated carcinogenic mice, skin tumor incidence and multiplicity were decreased to some extent in single ASO-, cinnamaldehyde- and gingerol-treated mice, whereas the oral C-ASO almost completely reduced susceptibility to skin carcinogenesis by cooperative ablation of enhanced lipid rafts, drastically suppressed phosphatidylinositol 3-Kinases (PI3K)/protein kinases A (Akt) signaling and decreased levels of nuclear transcription factor-kappa B (NF-κB) and cyclin D1 which reduced skin epithelial proliferation and epithelial-mesenchymal transition (EMT) during tumor genesis. This work supports C-ASO as a candidate functional food to prevent carcinogenesis.