alexa The Immunogenicity of Peptoid-Protein Conjugates | OMICS International | Abstract
ISSN: 2157-7560

Journal of Vaccines & Vaccination
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Short Communication

The Immunogenicity of Peptoid-Protein Conjugates

Allison Case1,2#, Angela Desmond1,3#, Daniel Lopes1,4, Kelly Dye1,5, Kelly Mapes1,6, Stephen Ruback1, Iliodora Pop1,7, Jiyeun Kate Kim1,8, Pavitra Chakravarty1, Joan E. Smallshaw1, Laurentiu M. Pop1,9 and Ellen S.Vitetta1,10*

1Cancer Immunobiology Center and Department of Immunology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

2Department of Bioengineering, The University of Texas at Dallas, Texas, USA

3Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA

4Eli Lilly, Indianapolis, Indiana, USA

5School of Medicine, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

6Green Center for Systems Biology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

7Department of Neuroscience, University of Texas Southwestern Medical Center, Dallas, Texas, USA

8College of Pharmacy, Pusan National University, Busan, Republic of Korea

9Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA

10Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

#Authors are equally contributed to this work.

*Corresponding Author:
Ellen S. Vitetta
Cancer Immunobiology Center and Department of Immunology
University of Texas Southwestern Medical Center
Dallas, Texas, USA
E-mail: [email protected]

Received date: June 20, 2016; Accepted date: July 06, 2016; Published date: July 11, 2016

Citation: Case A, Desmond A, Lopes D, Dye K, Mapes K, et al. (2016) The Immunogenicity of Peptoid-Protein Conjugates. J Vaccines Vaccin 7:329. doi: 10.4172/2157-7560.1000329

Copyright: © 2016 Case A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


We demonstrate that a peptoid composed of five monomers and attached via a maleimide linker to a carrier protein elicits anti-peptoid, anti-linker and anti-carrier antibodies in rabbits. Specific anti-peptoid antibodies were affinity purified and used to reproducibly retrieve three specific peptoid-coupled beads from 20,000 irrelevant peptoid-beads using magnetic screening.

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