alexa The Occurrence of Spontaneous Lymphomas but Not Adenomas or Sarcomas in Rats Treated With Sustained Release Naltrexone
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Research Article

The Occurrence of Spontaneous Lymphomas but Not Adenomas or Sarcomas in Rats Treated With Sustained Release Naltrexone

Erin Kelty1,3*, Philip K. Nicholls2, George O’Neil1,3, Zoe Harrison3, Chin-Tark Chan1,3, Peter Symons3, Albert Stuart Reece1,4 and Gary Hulse1

1Unit for Research and Education in Drugs and Alcohol, School of Psychiatry and Clinical Neurosciences (MDP 521), The University of Western Australia, Stirling Highway, Crawley, Western Australia, 6009

2School of Veterinary Biology and Biomedical Sciences, Murdoch University, South Street, Murdoch, Western Australia, 6150

3Go Medical Industries Ltd Pty, 200 Churchill Road, Subiaco, Western Australia, 6008

4Medical School, University of Queensland, St Lucia, Queensland, 4072

*Corresponding Author:
Erin Kelty
Go Medical Industries Ltd Pty
200 Churchill Road, Subiaco
WA 6008, Australia
Tel:
+61 8 9381 3226
Fax: +61 8 9382 4952
E-mail: [email protected]

Received Date: November 25, 2011; Accepted Date: January 02, 2012; Published Date: April 21, 2012

Citation: Kelty E, Nicholls PK, O’Neil G, Harrison Z, Chan CT, et al. (2012) The Occurrence of Spontaneous Lymphomas but Not Adenomas or Sarcomas in Rats Treated With Sustained Release Naltrexone. Clin Exp Pharmacol 2:105. doi: 10.4172/2161-1459.1000105

Copyright: ©2012 Kelty E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Naltrexone has been observed to have both a stimulatory and inhibitory effect on the development of tumours in rodents, potentially mediated by changes to the neuroendocrine system as a result of blockade of the opiate receptors, with the period of blockade and the tumour type thought to be influential. This study examined the occurrence of spontaneous tumours in rats treated with a sustained release naltrexone preparation. Materials and methods: 27 male and 27 female rats were randomized into three equal treatment groups (A, B and C). Rats in group A were implanted with a single naltrexone implant tablet, rats in group B were implanted with a single polymer implant tablet (placebo) and rats in group C underwent a sham procedure (control). Three different groups of spontaneous tumours were observed; lymphomas, adenomas and sarcomas. Lymphomas (4 tumours/3 rats) were observed solely in naltrexone treated rats, while adenomas (9 tumours/5 rats) and sarcomas (4 tumours/3 rats) were only observed in the placebo and the control groups. The data suggests that the association of naltrexone on the development of tumours maybe dependent on tumour type. Long term exposure to naltrexone appears to have both a stimulatory and inhibitory effect on tumours in rats, dependent on tumour type.

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