Reach Us +1-504-608-2390
The Prevention of New Sensitizations by Specific Immunotherapy: A Long-Term Observational Case Control Study | OMICS International | Abstract
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

The Prevention of New Sensitizations by Specific Immunotherapy: A Long-Term Observational Case Control Study

Andrzej Bozek1*, Radoslaw Gawlik2 and Jerzy Jarzab1

1Clinical Department of Internal Medicine, Dermatology and Allergology, Zabrze, Medical University of Silesia, Katowice, Poland

2Clinical Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, Katowice, Poland

*Corresponding Author:
Andrzej Bozek
Clinical Department of Internal Medicine, Dermatology and Allergology
Medical University of Silesia, M. Sklodowskiej-Curie 1041-800 Zabrze, Poland
Tel: 0048322713165
E-mail: [email protected]

Received date: June 06, 2013; Accepted date: July 11, 2014; Published date: July 18, 2014

Citation: Bozek A, Gawlik R, Jarzab J (2014) The Prevention of New Sensitizations by Specific Immunotherapy: A Long-Term Observational Case Control Study. J Allergy Ther 5:182. doi: 10.4172/2155-6121.1000182

Copyright: © 2014 Bozek A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Some studies have indicated that allergen specific immunotherapy (SIT) may prevent new sensitizations to other inhalant allergens; however, there are only a few longitudinal observations that have explored this event. The aim of this study was to perform a 20 year post-SIT observational analysis to assess the appearance of new sensitizations in SIT patients compared with non-SIT patients.
Material and methods: In total, 1,420 atopic bronchial asthma or/and allergic rhinitis patients (701 women and 719 men) with a mean age of 21.2 ± 9.2 years (at the time when the SIT concluded) were evaluated twenty years after their immunotherapies. New sensitization cases were determined by evaluating skin prick tests, allergen specific IgE and the clinical symptoms that were evaluated prior to and 5, 10, 15 and 20 years after SIT. The SIT group was compared with a control group consisting of 1,254 allergic patients who had never received SIT and had only received symptomatic treatments.
Results: After 20 years, 301 (21.2%) patients in the 4-5 year SIT group showed a new sensitization compared with 509 (40.6%) control group patients (p=0.004). In monosensitized SIT patients (n=886), there were significantly more new sensitizations in the control group (n=624): 69 (7.8%) vs. 195 (31.3%) (p=0.001). The odds ratio of the post-SIT new sensitization incidence in the whole group was 0.76 (95% CI: 0.55-0.92), whereas it was 1.32 in the control group (95% CI: 1.22-1.45).
Conclusion: The obtained data suggests a preventive role for specific immunotherapy in new sensitizations, especially in monosensitized patients.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2019-20
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri and Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

ankara escort

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

pendik escort

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2019 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version