Treating Chronic Pain with Mesenchymal Stem Cells: A Therapeutic Approach Worthy of Continued Investigation
- Corresponding Author:
- Ruth S Waterman
Ochsner Clinic Foundation
New Orleans, LA UNITED STATES
E-mail: [email protected]
Received Date: September 15, 2011; Accepted Date: October 19, 2011; Published Date: October 21, 2011
Citation: Waterman RS, Betancourt AM (2011) Treating Chronic Pain with Mesenchymal Stem Cells: A Therapeutic Approach Worthy of Continued Investigation. J Stem Cell Res Ther S2:001. doi:10.4172/2157-7633.S2-001
Copyright: © 2011 Waterman RS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Though there are various etiologies to chronic pain, one common feature is that painful states are associated with increased inflammation. This is verified by studies in both animal models and humans that have found increased expression of inflammatory proteins in muscle tissue, and increased inflammatory cytokines in cerebral spinal fluid, synovial fluid, and serum. Over the last decade we have become aware of the anti-inflammatory effects that multipotent mesenchymal stromal cells frequently referred to as mesenchymal stem cells [MSC], elicit. This ability of MSC to affect the inflammatory milieu has led researchers to consider MSC as a treatment for various painful states such as degenerative disc disease and osteoarthritis. In this article we present relevant animal and human studies, which indicate that MSC are worthy of further study as a valuable therapy in the treatment of chronic pain.