Special Issue Article
Uncommon Rh Phenotypes in a Cross Section of Nigerian Antenatal Women: Implications for Molecular Genotyping of Blood GroupsZaccheaus A Jeremiah1*, Amos A Biribo2, Teddy C Adias3 and Emmanuel K Uko4
- *Corresponding Author:
- Zaccheaus A Jeremiah
Department of Medical Laboratory Science College of Health Sciences Niger Delta University
E-mail: [email protected]
Received date: July 23, 2012; Accepted date: October 01, 2012; Published date: October 03, 2012
Citation: Jeremiah ZA, Biribo AA, Adias TC, Uko EK (2012) Uncommon Rh Phenotypes in a Cross Section of Nigerian Antenatal Women: Implications for Molecular Genotyping of Blood Groups. J Blood Disord Transfus S10:001. doi:10.4172/2155-9864.S10-001
Copyright: © 2012 Jeremiah ZA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: This study aimed to determine the frequency of rare blood group antigens among pregnant women in Port Harcourt Metropolis.
Methods: The frequencies of Rh antigens and phenotypes of the pregnant women in Port Harcourt Metropolis, Nigeria, were determined, using standard serologic techniques.
Results: Of the 374 pregnant women studied, the frequencies of the Rh antigens within the population were D (89.0%), c (82.0%), e (54.0%), C (24.3%), E (20.1%). The frequencies of the Rh antithetical antigens were DD/Dd (91.2 %), Cc (19,5%), cc (84.5%), Ee (13.9%), ee (54.3%), CC (25.1%), EE (19.8%) and dd (10.4%). Seven (1.9%) were found to be Rhnull, sixteen(4.3%) were found to be D-- or exalted D. Phenotypes without RhD reactivity were –c- (2.9%), - Cc (0.3%), -C- (0.3%), -Ee (0.5%) and –E- (0.3%). The most frequently occurring Rh phenotype was Dccee with a frequency of (25.8%). RhD-ve was found to be significantly associated with HDN outcome ( 2=6.605 and P=0.01).
Conclusion: We concluded that: 1) There is the presence of uncommon Rh phenotypes in our population. 2) Rhnull exists in this study population of which similar studies have not been reported in Nigeria. 3) There is need to conduct studies in other parts of Nigeria in order to compare the frequencies of these rare blood groups in Nigerian population. 4) Molecular studies to establish reasons for deletion and Rhnull phenotypes among Nigerian and Africans in general are hereby advocated.