alexa Unconventional Neurogenic Niches and Neurogenesis Modulation by Vitamins
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

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Review Article

Unconventional Neurogenic Niches and Neurogenesis Modulation by Vitamins

Karina Oyarce1, Ernesto R. Bongarzone2 and Francisco Nualart1*

1Laboratory of Neurobiology and Stem Cells, Center for Advanced Microscopy CMA BIO BIO, Concepcion University, Concepción, Chile

2Department of Anatomy and Cell Biology, College of Medicine, University of Illinois Chicago, USA

*Corresponding Author:
Francisco Nualart
Laboratory of Neurobiology and Stem Cells
Center for Advanced Microscopy CMA BIO BIO
Concepcion University, Concpción, Chile
Tel: +56-041-2203479
Fax: +56-041-2255479
E-mail: [email protected]

Received date: January 23, 2014; Accepted date: March 20, 2014; Published date: March 22, 2014

Citation: Oyarce K, Bongarzone ER, Nualart F (2014) Unconventional Neurogenic Niches and Neurogenesis Modulation by Vitamins. J Stem Cell Res Ther 4:184. doi: 10.4172/2157-7633.1000184

Copyright: © 2014 Oyarce K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Although the generation of new neurons occurs in adult mammals, it has been classically described in two defined regions of the brain denominated neurogenic niches: the subventricular zone of the lateral ventricles and the subgranular zone of the dentate gyrus. In these regions, neural stem cells give rise to new neurons and glia, which functionally integrate into the existing circuits under physiological conditions. However, accumulating evidence indicates the presence of neurogenic potential in other brain regions, from which multipotent precursors can be isolated and differentiated in vitro. In some of these regions, neuron generation occurs at low levels; however, the addition of growth factors, hormones or other signaling molecules increases the proliferation and differentiation of precursor cells. In addition, vitamins, which are micronutrients necessary for normal brain development, and whose deficiency produces neurological impairments, have a regulatory effect on neural stem cells in vitro and in vivo. In the present review, we will describe the progress that has been achieved in determining the neurogenic potential in other regions, known as unconventional niches, as well as the characteristics of the neural stem cells described for each region. Finally, we will revisit the roles of commonly known vitamins as modulators of precursor cell proliferation and differentiation, and their role in the complex and tight molecular signaling that impacts these neurogenic niches.


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