alexa Urinary Study on the Biochemical Effect of Acupuncture on Monosodium Urate Crystals-Induced Acute Gouty Arthritis in Rats using 600MHz 1H NMR
ISSN: 0975-0851

Journal of Bioequivalence & Bioavailability
Open Access

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Research Article

Urinary Study on the Biochemical Effect of Acupuncture on Monosodium Urate Crystals-Induced Acute Gouty Arthritis in Rats using 600MHz 1H NMR

Yu Chen1, Li-Ping Wu2, Yu-Jie Liu3, Peng-Chi Deng4, Hai-Lin Yin5, Si-Lan Wen3, Cong Chen3 and Li-Ming Ye3*

1West China Hospital, Sichuan University, Chengdu, 610041, PR China

2Chengdu Women and Children Cesssssntral Hospital, Chengdu, 610091, China

3West China School of Pharmacy, Sichuan University, Chengdu, 610041, PR China

4Analytical Center, Sichuan University, Chengdu, 610041, PR China

5Laboratory Animal Center, Sichuan University, Chengdu, 610041, PR China

*Corresponding Author:
Li-Ming Ye
West China School of Pharmacy
Sichuan University, NO.17
Block 3 South Renmin Road
Chengdu, 610041, People’s Republic of China
Tel: (+86)13980986791
Fax:
(+86)02885502305
E-mail:
[email protected]

Received Date: March 03, 2012; Accepted Date: October 26, 2012; Published Date: October 31, 2012

Citation: Chen Y, Wu LP, Liu YJ, Deng PC, Yin HL, et al. (2012) Urinary Study on the Biochemical Effect of Acupuncture on Monosodium Urate Crystals-Induced Acute Gouty Arthritis in Rats using 600MHz 1H NMR. J Bioequiv Availab 4: 106-111. doi: 10.4172/jbb.1000122

Copyright: © 2012 Chen Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Acupuncture may potentially be an alternative therapy for acute gouty arthritis, a common inflammation model with multiple pathogenic mechanisms. In order to investigate the biological process of acute gouty arthritis and the effect of acupuncture, 1 H nuclear magnetic resonance (NMR)-based metabonomics has been applied to acquire urine metabolom data. Acute gouty arthritis model rats were induced by monosodium urate (MSU) crystals. The acupuncture on ST-36 (Zusanli) and SP-6 (Sanyinjiao) acupoints was applied for nine consecutive days. Principal Components Analysis (PCA) and Partial Least Squares (PLS) have been used to compare the time course urine metabolic perturbations. The prominent changes in endogenous urinary metabolites in acute gouty arthritis rats comprised increased levels of citrate and succinate, and decrease of allantoin, lactate, formate, trimethyl-N-oxide (TMAO) and taurine on the 3 rd day after MSU injection; and on day 9, Citrate, succinate, and allantoin began to recover to the original level, whereas formate, taurine, TMAO and lactate further decreased, which showed their incompletely recovery. Acupuncture treatment appears to reverse the levels of most metabolites affected by acute gouty arthritis, however, with significant increase levels of acetate, acetoacetate, allantoin, creatine/creatinine, phenylacetylglycine (PAG), taurine and TMAO on day 3; all these metabolites began to recover to the original level on day 9 except for creatine/creatinine, which slightly increased, demonstrating the therapeutic effects of acupuncture on acute gouty arthritis. Our work shows the potential of an NMR-based metabonomic approach in the study of biological effects of acupuncture on acute gouty arthritis

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