alexa Vascular Function in Fibromuscular Dysplasia | OMICS International
ISSN: 2329-6925

Journal of Vascular Medicine & Surgery
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Research Article

Vascular Function in Fibromuscular Dysplasia

Nicole Wake1,2*, Iñaki Marina3 and Jeffrey W Olin4

1Center for Advanced Imaging Innovation and Research, Center for Biomedical Imaging, Department of Radiology, New York University School of Medicine, New York, USA

2The Sackler Institute for Graduate Biomedical Sciences, New York University School of Medicine, New York, USA

3Hospital de Viladecans, Institut Català de la Salut, Barcelona, Spain

4Zena and Michael A. Wiener Cardiovascular Institute and Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Icahn School of Medicine at Mount Sinai,New York, USA

*Corresponding Author:
Nicole Wake
Department of Radiology
New York University School of Medicine
660 First Avenue, New York, USA
Tel: 212263-3309
E-mail: [email protected]

Received Date: March 07, 2015; Accepted Date: April 06, 2015; Published Date: April 08, 2015

Citation: Wake N, Marina I, Olin JW (2015) Vascular Function in Fibromuscular Dysplasia. J Vasc Med Surg 3:196. doi: 10.4172/2329-6925.1000196

Copyright: ©2015 Wake N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: There have been no studies to date on the pathophysiologic mechanisms of how fibromuscular dysplasia (FMD) affects vascular function. Due to the perturbations in the blood vessel wall and the propensity for stenosis, dissection, and aneurysms seen in arteries with FMD, subjects with FMD may have impairment in endothelial function and abnormalities in arterial compliance.

Methods: Twenty-seven subjects with documented FMD of the renal and/or carotid arteries and ten age, gender, and ethnicity matched healthy control subjects were recruited for this study. Predictors of cardiovascular disease including endothelial function, brachial-ankle pulse wave velocities (baPWVs), ankle-brachial indices (ABIs), and carotid artery intima-media thickness (IMT) were evaluated.

Results: For the FMD population, endothelium dependent flow-mediated vasodilation of the brachial artery was 15.91 ± 8.69% (p<0.001). Nitroglycerin produced a significant 27.69% (p=0.04) increase in time-averaged, volumetric flow through the brachial artery and resulted in an increase in brachial artery diameter from 2.66 ± 0.42 mm to 3.37 ± 0.51 mm, p<0.01. The mean baPWV for all ages was 1324.37 ± 247.55 cm/sec, the mean ABI was 1.16 ± 0.09, and the mean distal common carotid artery far wall IMT was 0.64 ± 0.15 mm.

Conclusion: This is the first study to evaluate vascular function in FMD. In this small population, FMD was not associated with endothelial dysfunction, impaired arterial compliance, increased carotid artery IMT, or decreased ABIs. A prospective larger study will be required to confirm these findings.

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