alexa Voltammetric Determination of Isoniazid using Cyclic Renewable Mercury Film Silver Based Electrode | OMICS International | Abstract
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Research Article

Voltammetric Determination of Isoniazid using Cyclic Renewable Mercury Film Silver Based Electrode

Marek Szlósarczyk1*, Robert Piech2, Beata Paczosa Bator2, Anna Maslanka1, Wlodzimierz Opoka1 and Jan Krzek1

1Department of Inorganic and Analytical Chemistry, Medical College, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland

2Faculty of Materials Science and Ceramics, AGH University of Science and Technology, Al. Mickiewicza 30, 30-059 Kraków, Poland

*Corresponding Author:
Marek Szlósarczyk
Department of Inorganic and Analytical Chemistry
Jagiellonian University, Medical College, 30–688 Kraków
Medyczna 9, Poland
Tel: +48 12 6205480
Fax: +48 12 6205480
E-mail:[email protected]

Received date: August 17, 2012; Accepted date: November 23, 2012; Published date: November 26, 2012

Citation: Szlósarczyk M, Piech R, Bator BP, Maslanka A, Opoka W, et al. (2012) Voltammetric Determination of Isoniazid using Cyclic Renewable Mercury Film Silver Based Electrode. Pharmaceut Anal Acta 3:189. doi: 10.4172/2153-2435.1000189

Copyright: © 2012 Szlósarczyk M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

A new cathodic voltammetry method for the determination of isoniazid based on the cyclic renewable mercury film silver based electrode (Hg (Ag) FE) is presented. The effects of various factors such as: preconcentration potential and time, pulse height, step potential and supporting electrolyte composition are optimized. The calibration graph is linear from 5 nM up to 500 nM (68.55 μgL-1). For Hg (Ag) FE with a surface area of 9.7 mm2 without time consuming preconcentration the limits of detection LOD and quantification LOQ were 4.1 nM and 10.5 nM of isoniazid, respectively. The repeatability of the method at a concentration level of the analyte as low as 0.5 nM, expressed as RSD is 3.6% (n=6). The proposed method was successfully applied in analysis of isonizid in simple and composed pharmaceutical formulations.

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