alexa ZH501-VSVRI: Is it Still the Best Choice for Vaccination Against Rift Valley Fever in Egypt? | OMICS International | Abstract
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

ZH501-VSVRI: Is it Still the Best Choice for Vaccination Against Rift Valley Fever in Egypt?

Mohamed H Atwa1, Ibrahim M El-Sabagh2,3, Haitham M Amer2,4*, Samy Saad1, Ausama A Yousif2 and Mohamed A Shalaby2

1Veterinary Serum and Vaccine Research Institute, Abbasia, Egypt

2Department of Virology, Faculty of Veterinary Medicine, Cairo University, 12211, Giza, Egypt

3Central Biotechnology Laboratory, College of Veterinary Medicine and Animal Resources, King Faisal University, Al-Hasaa, Saudi Arabia

4Department of Botany and Microbiology, College of Science, King Saud University 11451, Riyadh, Saudi Arabia

*Corresponding Author:
Haitham M Amer
Department of Botany and Microbiology
College of Science, King Saud University
P.O. Box 2455, Riyadh 11451
Kingdom of Saudi Arabia
Tel: +966-44336482
Fax: +966-4675833
E-mail: [email protected]

Received date: May 21, 2011; Accepted date: August 22, 2011; Published date: August 24, 2011

Citation: Atwa MH, El-Sabagh IM, Amer HM, Saad S, Yousif AA, et al. (2011) ZH501-VSVRI: Is it Still the Best Choice for Vaccination Against Rift Valley Fever in Egypt? J Vaccines Vaccin 2:121. doi:10.4172/2157-7560.1000121

Copyright: © 2011 Atwa MH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


ZH501 strain of Rift valley fever virus (RVFV) was originally isolated from a human patient during the outbreak of 1977 in Egypt. This virus strain was used since 1980 for preparation of an inactivated RVF vaccine at Veterinary Serum and Vaccine Research Institute (VSVRI), Egypt. Two subpopulations of ZH501 with a single nucleotide polymorphism (A/G) at nucleotide position 847 of Gn gene of M segment have been described. This nucleotide substitution affected significantly RVFV virulence in the mouse model. In this report, the genetic makeup of the Gn gene of ZH501-VRVSI vaccine virus stock was analyzed for verification of its safety and stability. Plaque assay of the vaccine stock virus revealed the presence of two populations that produced different plaque forms. The viruses that developed large plaques resembling those produced by the virulent virus strains were isolated for genetic analysis. Comparison of the Gn gene nucleotide sequence of the isolated viruses with those of the wild-type ZH501 and other reference strains identified five nucleotide substitutions, of which three are capable to induce amino acid changes in the mature protein. Protean analysis suggested a potential change in the three dimensional structure of the Gn protein in relation to the parent strain. The results of this study throw light on the changes occurred in the master seed virus used for preparation of RVFV vaccine in Egypt. Further studies focusing on the other gene segments of ZH501-VSVRI are required to conclude is it still the best choice for vaccination against RVF in Egypt.


Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7