alexa A Computerized Physician Order Entry Set Designed To Improve Safety Of Intravenous Haloperidol Utilization
ISSN: 2329-6887

Journal of Pharmacovigilance
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference and Exhibition on Pharmacovigilance & Clinical Trials
November 18-19, 2013 Hilton San Antonio Airport, TX, USA

Andrew J. Muzyk
Accepted Abstracts: J Pharmacovigilance
DOI: 10.4172/2329-6887.S1.009
Abstract
The risks of antipsychotic-induced corrected QT (QTc) prolongation and sudden cardiac death have been documented since the early 1960s. Prolongation of the QT interval can lead to torsades de pointes (TdP), a ventricular tachyarrhythmia associated with presyncope, syncope and sudden death. All antipsychotics have the propensity to lengthen the QTc; however, a 2007 US FDA alert highlighted increased risk of QTc prolongation, TdP and sudden cardiac death with the off-label intravenous administration of haloperidol and prompted specific language in haloperidol?s package insert. In response, haloperidol?s package insert now recommends cautious use in patients with predisposing risk factors for QT-prolongation and recommends ECG monitoring. The purpose of this study was to examine the effects of implementation of the CPOE set on adherence to monitoring parameters, maximum and cumulative doses, and identification or mitigation of risk factors for QTc prolongation in patients prescribed intravenous haloperidol. The study was designed to test the null hypothesis that the cumulative daily dose of intravenous haloperidol, the frequency of baseline and routine ECG monitoring, and routine electrolyte monitoring would be the same before and after implementation of the CPOE set; the experimental hypothesis was that these parameters would differ after implementation of the CPOE set. This study reports on the successful implementation of a CPOE set designed to improve the safety of intravenous haloperidol administration, which is commonly used for the off-label treatment of agitation among medically ill and delirious patients. The findings from this study demonstrate that the use of an order set improved a number of patient safety measures, important when prescribing intravenous haloperidol, such as ECG and electrolyte monitoring. Additionally, there was a reduction in the proportion of subjects who received intravenous haloperidol ≥2 mg in 24 hours. Rates of concomitantly-prescribed QTcprolonging medications were unchanged following order set implementation. Decision support or other mechanisms to help prescribers identify and minimize concomitant QTc-prolonging medications may be a beneficial strategy for future interventions aimed at optimizing the safety of intravenous haloperidol prescription.
Biography
Andrew J. Muzyk completed his PharmD from Mercer University Southern College of Pharmacy and Health Sciences followed by two years of postdoctoral training to specialize in Medicine-Psychiatry. He is currently an Assistant Professor at Campbell University College of Pharmacy and Health Sciences in the Department of Pharmacy Practice and has an adjunct appointment in the Department of Psychiatry and Behavioral Sciences at Duke University. He rounds with the Medicine-Psychiatry team at Duke and with his colleagues. He publishes and performs research on the treatment of delirium, alcohol withdrawal, and use of psychotropics in a medically ill patient population. Additionally, he is active in several medicine and pharmacy organizations and has served as a reviewer for multiple journals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords