alexa A Novel Form Of 4-1BB Ligand As A Potent And Safe Adjuvant For Development Of Therapeutic Cancer Vaccines
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

3rd International Conference on Vaccines & Vaccination
July 29-31, 2013 Embassy Suites Las Vegas, NV, USA

Rajesh Kumar Sharma
ScientificTracks Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.016
Abstract
S ubunit cancer vaccine represents an attractive treatment option due to tumor specificity, ability to generate memory, and safety. However, they require potent adjuvants for therapeutic efficacy due to weak immunogenicity of TAAs and potential self-tolerance. Given costimulation is intrinsically evolved to augment antigen specific T cell responses required for antitumor immunity, we tested if a costimulatory molecule 4-1BBL can serve as an effective adjuvant component of the TAA based vaccine formulations. To achieve this goal, we used ProtEx? for generation of chimeric SA-4-1BBL that exist as stable tetramers and higher structures, and as such can be used as soluble proteins to effectively crosslink 4-1BB receptor on immune cells for potent signal transduction. We herein describe a novel vaccine approach based on the use of this novel SA-4-1BBL protein as adjuvant with various TAAs in several cancer immunotherapy mouse models. One vaccination with the E7 or survivin with SA-4-1BBL resulted in the eradication of existing E7 expressing cervical and survivin over expressing 3LL lung tumors in >70% of the animals. This efficacy was improved to 100% when multiple vaccinations were used. Importantly, animals with successful immunotherapy developed a robust CTL responses and NK cell cytotoxicity against the tumor and long-term immune memory which was tumor antigen specific. Vaccine was well tolerated and showed no sign of overt toxicity or autoimmunity. Chimeric SA-4-1BBL has the potential to serve as a specific immunological adjuvant to develop T cell based therapeutic vaccines against tumors with well characterized tumor associated antigens
Biography
Rajesh Kumar Sharma is a Faculty of Department of Medicine at University of Louisville, Louisville, KY. He completed his Ph.D. in the area of infectious immunology at Banaras Hindu University in India. He then moved to USA to pursue his postdoctoral studies in the area of cancer immunology/immunotherapy and therapeutic cancer vaccines at the Institute for Cellular Therapeutics, at University of Louisville. Dr. Sharma serves as Editorial Board member and reviewer for various journals. His research interests are in the area of cancer immunology & immunotherapies, particularly development of combinatorial approaches such as chemo-immunotherapy. He has widely published in journals of Immunology, and Cancer Research.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

engineeringjou[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords