alexa A2A-mediated Angiogenesis In Human And Animal Models
ISSN: 2329-6925

Journal of Vascular Medicine & Surgery
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

World Congress on Vascular Diseases, Medicine & Surgeons Summit
October 24-25, 2016 Chicago, USA

Carlos Escudero
Universidad Del Bio Bio, Chile
Posters & Accepted Abstracts: Vasc Med Surg
DOI: 10.4172/2329-6925.C1.003
Abstract
We have characterized the role of A2A receptor on angiogenesis using human and mice endothelial cells. Firstly, using pharmacological and gain-loss analysis with A2A receptors, we demonstrated that A2A receptor stimulation triggers an intracellular pathway leading to endothelial nitric oxide synthase (e-NOS) activation and nitric oxide synthesis, which in turn was associated with increase in the vascular endothelial growth factor (VEGF) expression in human umbilical vein endothelial cells (HUVEC), derived from normal pregnancies. This particular pathway is differentially impaired in preeclampsia considering gestational age of clinical diagnosis, in which reduced A2A-NO-VEGF signaling has been evidenced in early onset pre-eclampsia (<35 weeks of gestation); whereas in late onset pre-eclampsia (>35 weeks of gestation) is increased. Extending our results in A2A-mediated angiogenesis, recently we have studied wound healing in mice lacking of A2A receptors (A2AKO). Results indicate that compared to respective wild type animals, female A2AKO, but not male A2AKO, exhibited increased wound healing. This result was associated to increased dermis length and dermal capillary blood flow in female A2AKO compared to either wild type or male A2AKO. Furthermore, compared to respective wild type and using pulmonary endothelial cells we found that whereas female A2AKO expressed high levels of A2B and A3 receptors, male exhibited elevated A1 but reduced A2B, without changes in A3 mRNA levels. Functional significance of these changes showed that female A2AKO animals, but not male A2AKO, exhibited increased adenosine receptors-mediated angiogenesis capacity. Thus A2A adenosine receptor is controlling VEGF expression and angiogenesis processes in human and animal models. Alteration in these processes might be differentially present in human diseases such as pre-eclampsia or in female A2AKO animals.
Biography

Email: [email protected]

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords