alexa Antifungal Effect Of Low Molecular Weight Chitosan Against Candida Albicans: An In Vivo Study | 69223
ISSN: 2161-1122

Dentistry
Open Access

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23rd Global Dentists and Pediatric Dentistry Annual Meeting
July 17-18, 2017 Munich, Germany

N Salehi and A Salehi
Rafsanjan University of Medical Sciences, Iran
Posters & Accepted Abstracts: Dentistry
DOI: 10.4172/2161-1122-C1-021
Abstract
This study investigated the antifungal effect of low molecular weight chitosan solution and compared it with nystatin suspension. This randomized single-blind clinical trial study was performed on 40 subjects diagnosed with denture stomatitis. The subjects were divided into two groups, one of which was treated with chitosan and one with nystatin for two weeks. Changes in the erythematous area were recorded during and after treatment. A palatal smear was obtained for each patient before and after treatment to determine the number of blastospores and mycelia of Candida albicans. The results were compared using the Mann-Whitney test and t-test. The results showed that chitosan solution significantly decreased the erythematous surface area, burning sensation, time required for clinical improvement, and number of blastospores and mycelia. The antifungal efficacy and biocompatibility of chitosan makes it a promising candidate for use as an antifungal mouthwash.
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