Dentistry

Antifungal effect of low molecular weight chitosan against Candida albicans: An in vivo study

23^rd Global Dentists and Pediatric Dentistry Annual Meeting

July 17-18, 2017 Munich, Germany

N Salehi and A Salehi

Rafsanjan University of Medical Sciences, Iran

Posters & Accepted Abstracts: Dentistry

Abstract:

This study investigated the antifungal effect of low molecular weight chitosan solution and compared it with nystatin suspension. This randomized single-blind clinical trial study was performed on 40 subjects diagnosed with denture stomatitis. The subjects were divided into two groups, one of which was treated with chitosan and one with nystatin for two weeks. Changes in the erythematous area were recorded during and after treatment. A palatal smear was obtained for each patient before and after treatment to determine the number of blastospores and mycelia of Candida albicans. The results were compared using the Mann-Whitney test and t-test. The results showed that chitosan solution significantly decreased the erythematous surface area, burning sensation, time required for clinical improvement, and number of blastospores and mycelia. The antifungal efficacy and biocompatibility of chitosan makes it a promising candidate for use as an antifungal mouthwash.

Biography :

Email: negarsal66@gmail.com