alexa Chitosan/HA Composite Scaffolds For Controlled Drug Delivery
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

4th International Conference on Nanotek & Expo
December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Bushra Iqbal, Ayesha Idrees, Azhar Hayat Nawaz, LubnaShahzadi, Muhammad Yar and Ather Farooq Khan
Accepted Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.019
Abstract
Trabecular bone is severely affected by osteoporosis, therefore porous scaffolds identical to trabecular bone in porosity, density, and biomechanical properties are an area of intense research. In an effort, HPMC mediated synthesis of scaffolds containing HA and chitosan (CS) as major inorganic and organic phases; a mixture of HA, CS, and HPMC was homogenized and freeze dried to yield highly porous composite scaffolds. Five different compositions having different concentration of HPMC were synthesized. These scaffolds were characterized by FTIR, XRD, DSC-TG, UTM and SEM.The in vitro biodegradation of the composite scaffolds in the PBS solution with different incubation times was also investigated. The biocompatibility testing was performed through cell culturing techniques. Then thescaffolds were loaded with antibiotic (ibuprofen), and the release profile was checked. Scaffolds with different HPMC concentrations were elaborated with specific internal porosities for using as antibiotic carrier materials. UV spectrophotometry and bacteria inhibition tests (against S. aureus and E. coli) were performed for testing the antibiotic adsorption and the microbiological effectiveness after loading with Ibuprofen. The micro-porosity of scaffolds with different HPMC concentrations had different release times of antibiotics under mimic physiological conditions. Moreover, the PCL polymer, as a coating component, was used to effectively entrap the drug. PCL was coated prior to drug loading, as well as ?simultaneous drug loading and PCL coating? experiment was performed to compare the release profile in both of the cases. The results suggested the possibility of a controlled drug release in the porous scaffold with PCL coating.
Biography
Bushra Iqbal has completed her MS from University of The Punjab, Lahore, Pakistan at the age of 23. She is working as a Research Associate in Interdisciplinary Research Centre In Biomedical Materials, COMSATS Institute of Information Technology, Lahore Pakistan from last three years. Her current research is focused on the synthesis of composite scaffolds for controlled drug delivery.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords