alexa Depressive Episode Incidence In Patients With Chronic Hepatitis C Treated With Pegylated Interferon And Ribavirin
ISSN: 2167-0889

Journal of Liver
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

CO-ORGANIZED EVENT: 5th World Congress on Hepatitis & Liver Diseases & 2nd International Conference on Pancreatic Cancer & Liver Diseases
August 10-12, 2017 London, UK

Izabella Liguori Corsino Vabo
Federal University of Juiz de Fora, Brazil
Hospital and Maternity Therezinha de Jesus, Brazil
Posters & Accepted Abstracts: J Liver
DOI: 10.4172/2167-0889-C1-015
Abstract
Statement of the Problem: The effectiveness of antiviral therapy with pegylated interferon and ribavirin for chronic hepatitis C is far from ideal and presents several adverse events. Among such events, there is the depressive episode that can even lead to treatment discontinuity. Objective: The objective of the study was to analyze the incidence of depressive episodes in patients with chronic hepatitis C treated with pegylated interferon and ribavirin, as well as the possible factors associated with its occurrence and its impact on patients sustained virological response. Materials & Methods: People with chronic hepatitis C undergoing antiviral therapy were interviewed at the baseline, at the 4th, 12th, 24th and 48th treatment weeks and 4 weeks after the end of it, using the HADS (Hospital Anxiety and Depression Scale) scale for tracking the depressive episode. Patients with HADSā‰„9 were subjected to Beck Depression Inventory (BDI-II) to grade the episode. Clinical, socio, demographic, laboratorial and histological variables were obtained to identify factors related to the onset of depression. The sustained virological response rate (negative HCV-RNA 6 months after end of therapy) was compared among patients with and without depressive symptoms. Results: The study comprised 32 patients. The depressive episode was diagnosed in 25% of the patients and the peak incidence was found in the 12th treatment week. The depressive episode was moderate in 87% of the patients. None of the analyzed factors was associated with depressive episode onset. A trend was observed in female patients. The sustained virological response rate was of 75% and 67% in patients with and without depressive episode, respectively. Conclusion & Significance: The study shows that the incidence of depressive episodes in Brazilian patients with chronic hepatitis C treated with PEG IFN alpha and ribavirin, is high. It is recommended that patients undergoing antiviral therapy with pegylated interferon should be systematically evaluated in search for depressive episode, especially in the first 12 weeks of therapy, since the depressive episode affects a significant number of treated patients.
Biography

Izabella Liguori Corsino Vabo is a Clinical and Hospital Psychologist and Cognitive-Behavioural Therapist from Brazil. She pursued Master’s degree in Health at Federal University of Juiz de Fora, Brazil with emphasis on research in chronic hepatitis C. She is the Coordinator in the Department of Hospital Psychology, Hospital and Maternity Therezinha de Jesus, Juiz de Fora, MG, Brazil. She has been working for more than 10 years in this area.

image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords