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Development of Epigenetic Nanoparticulate Drug Formulations for Cancer
10th International Conference on Nanomedicine and Nanotechnology in Health Care
July 25-27, 2016 Bangkok, Thailand
Duc P Do
Chicago State University College of Pharmacy, USA
Posters & Accepted Abstracts: J Nanomed Nanotechnol
Abstract:
The development of oral anticancer drug formulations is highly desired. The main objective of the present research was to develop modified-release oral capsule formulations containing histone deacetylase inhibitor (HDACI)-encapsulated albumin nanoparticles. Nanoparticles were prepared by spray drying using bovine serum albumin as the polymer and were evaluated as a potential drug delivery system for providing extended-release of oral drug formulations. HDACIs, which are epigenetic agents, have emerged as a promising class of drugs. Instead of altering the primary DNA sequence, HDACIs reverse aberrant epigenetic changes in cancer cells. Our talk will present recent data on the potential of using capsules containing biodegradable albumin microspheres as a platform technology for the oral extended-release delivery of HDACI for breast cancer.
Biography :
Email: ddo@csu.edu