alexa Evaluation Of Hepatoprotective Activity Of Ixora Coccinea Against Xenobiotics Induced Liver Damage In Alloxan Induced Diabetic Rats
ISSN: 2329-6887

Journal of Pharmacovigilance
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Conference and Exhibition on Pharmacovigilance & Clinical Trials
November 18-19, 2013 Hilton San Antonio Airport, TX, USA

Ramesh Alluri, Rajashekar Perusomula and Kashivishwanath Routhu
Accepted Abstracts: J Pharmacovigilance
DOI: 10.4172/2329-6887.S1.009
Abstract
The objective was to evaluate hepatoprotective activity of Ixora coccinea (IC) against xenobiotics induced liver damage in alloxan induced diabetic rats. Wistar rats of either sex (250?5 gm) were divided into 5 groups. Animals of (Group-1) were non diabetic and received 4 ml/kg p.o allyl alcohol. Diabetes was induced by alloxan (160 mg/kg i.p). Diabetic animals were divided into control (Group-2), ally alcohol (Group-3), IC (600 mg/kg p.o + ally alcohol 4 ml/kg p.o Group-4). Allyl alcohol administration in diabetic animals showed increased necrosis index compared to non diabetic group. Treatment of animals with IC 600 mg/kg showed dose dependent reduction of necrosis index. In separate group of non diabetic and diabetic animals thioacetamide (300 mg/kg i.p) was administered to induce hepatotoxicity on day 6. Group-1 non diabetic control (distill water p.o), Group-2 non diabetic thioacetamide, group 3 diabetic control, Group-4 diabetic thioacetamide control (300 mg/kg i.p), Group-5 (thioacetamide+IC 600 mg/kg p.o). Blood samples and liver samples were collected on day 8. Thioacetamide produced increase in serum AST & ALT levels in both non diabetic and diabetic animals. There was significant increase in serum AST & ALT levels observed in diabetic animals when compared to non diabetic animals. IC (600 mg/kg, for 8 days) showed significant reduction in serum AST & ALT levels compared to thioacetamide (300 mg/kg) group. Histopathology results correlated with biochemical parameters. It is concluded that IC (600 mg/kg) showed hepatoprotective effect in both allyl alcohol and thioacetamide induced hepatotoxicity in both diabetic and non diabetic animals.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords