alexa Extended Action Of FIX For Improving The Lifestyle Of Hemophiliacs
ISSN: 2155-9864

Journal of Blood Disorders & Transfusion
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Conference on Hematology & Blood Disorders
September 23-25, 2013 DoubleTree by Hilton Hotel Raleigh-Durham Airport at RTP, NC, USA

Darrel W. Stafford
Accepted Abstracts: J Blood Disord Transfus
DOI: 10.4172/2155-9864.S1.004
Abstract
Several pharmaceutical companies are in the process of developing Factor IX (FIX) molecules with a longer half-life. The goal of this is to improve the lifestyle of patients with hemophilia by decreasing their frequency of injection of coagulation FIX. Biogen IDEC has developed a FIX molecule with a Fc terminal extension that is purported to be re-cycled vita the Fc receptor. NovoNordisk developed a new FIX that has had PEG added to one of its N-Glycosylation sites in its activation peptide. Behring has developed a longer lasting FIX molecule that has albumin added to its C-terminus. The albumin has a FXI cleavage site and is cleaved when FIX is activated. All of these molecules are considerably larger than normal FIXWT, and may not be distributed normally into the extra- vascular space where much of FIX normally resides. FIX has been shown to bind tightly and reversibly to type IV collagen which underlies all endothelial cells. This binding is correlated with the observation that much of FIX seems to be located extra- vascularly. We have recently shown that normal FIX can protect hemophilia B mice for up to 7 days after infusion, well after the FIX has disappeared from circulation. Therefore, extravascular FIX plays an important role in hemostasis and may be the most relevant compartment for coagulation. The distribution of these new longer lasting factor IX molecules needs to be established.
Biography
Darrel W. Stafford completed his Ph.D. at the age of 29 years from the University of Miami. He attended Albert Einstein Medical School in New York for his post-doctoral work. He is currently a professor of Biology and Pathology at the University of North Carolina at Chapel Hill. He has published ~198 peer-reviewed papers in many reputable journals. His laboratory is known for having purified and cloned both VKOR and gamma-glutamyl carboxylase of the vitamin K cycle.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords