alexa Genotyping Harboring A Second Flagellin Gene Of Salmonella Enterica Serovar Typhi In Indonesia Endemic Areas
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

2nd International Congress on Bacteriology & Infectious Diseases
November 17-19, 2014 DoubleTree by Hilton Hotel Chicago-North Shore, USA

Mochammad Hatta
Accepted Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.008
Abstract
The genome of S. Typhi is highly conserved. However, S. Typhi strains from Indonesia were reported that harbored, instead of the S. Typhi specific Hd flagellin gene, a mutant flagellin gene (Hj) with a deletion in the conserved region or that carried, as a second flagellin gene, the z66 or Ind flagellin gene. Flagella may function in several properties include motility, cell entry, immune evasion and sensing of environmental conditions. The z66 and Ind flagellin genes were detected in, respectively, 23.1% and 26.5% of 363 Salmonella enterica serovar Typhi blood culture isolates from typhoid patients in east Indonesia and are associated with severe illness characterized by apathy and stupor (relative risk, 2.48; 95% confidence interval, 1.17-5.27). Multi-locus variable-number tandem repeat analysis identified 89 genotypes. The proximate location in papua of the homes of patients infected with almost identical genotypes containing the z66 gene is consistent with vertical transmission of the gene to their progeny. A spatial clustering of five divergent genotypes harboring the Ind gene revealed its horizontal transmission. Evidence to show capacity of S. Typhi to express different flagella increases the risk for severe disease characterized by apathy and stupor is presented. Spatial cluster analysis of the homes of typhoid patients provided supportive evidence for the vertical spread of the z66 flagellin gene to the progeny of two closely related genotypes and for the transfer of the Ind flagellin gene to several only distantly related genotypes revealing ongoing horizontal transmission. Cluster analysis of distinct genotypes may also be used to look for major sources of transmission and carriers. However, the large diversity in genotypes shows that the number of carriers can be large.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords