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Histopathological Studies In Plant Extract Treated Alloxan Induced Diabetic Rats | 7828
ISSN : 2153-2435

Pharmaceutica Analytica Acta
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Histopathological studies in plant extract treated Alloxan induced Diabetic Rats

2nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

Arunjothi B, Chakrapani P and Anupalli Roja Rani

Posters: PAA

DOI: 10.4172/2153-2435.10000S5

Abstract
Diabetes mellitus is a chronic metabolic disorder resulting from insulin defi ciency characterized by hyperglycaemia, an altered metabolism of carbohydrates, protein and lipids and an increased risk of vascular complication. In conventional therapy type-I diabetes is managed with exogenous insulin and type-II with oral hypoglycemic agents (sulphonylureas, biguanides etc). In traditional practice medicinal plants are used in many countries to control diabetes mellitus. Alloxan, a drug which is widely used to induce experimental diabetes in animals and its mechanism of action in β cells of the pancreas has been intensively investigated. Th e cytotoxic action of this diabetogenic agent is mediated by reactive oxygen species and its product of reduction, the dialuric acid, establishes a redox cycle with the formation of superoxide radicals that undergo dismutation to hydrogen peroxide. Th e objective of this study is to investigate the histopathology of diabetes treated rats. Th e eff ect of methanolic extract (300 and 500 mg/kg body weight) of Erythrina indica stem bark on alloxan - induced diabetic rats was studied. Th e histopathological study was investigated in the liver, kidney and pancreatic tissue sections. Pathological lesions were evoked in diabetic rat cells. Th e extract improves the function of liver, kidney, pancreas and reduce the lesions associated with diabetic state in alloxan induced rats. Th e eff ect of oral administration of Erythrina indica at a dose of 500 mg/kg body weight was more effi cient than the 300 mg/kg body weight. Th e results indicate the protective eff ect of methanol extract on tissues and prove its potential as an antidiabetic agent.
Biography
Arunjyothi.B pursuing Ph.D under Dr. Anupalli Roja Rani (Associate Professor), Department of Genetics, Osmania University, Hyderabad-500007, Andhra Pradesh, India.
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