Pharmaceutica Analytica Acta

Histopathological studies in plant extract treated Alloxan induced Diabetic Rats

2^nd World Congress on Bioavailability & Bioequivalence: Pharmaceutical R & D Summit-2011 and International Conference on Pharmaceutics & Novel Drug Delivery Systems

06-08 June 2011, Las Vegas, USA

Arunjothi B, Chakrapani P and Anupalli Roja Rani

Posters: PAA

Abstract:

Diabetes mellitus is a chronic metabolic disorder resulting from insulin defi ciency characterized by hyperglycaemia, an altered metabolism of carbohydrates, protein and lipids and an increased risk of vascular complication. In conventional therapy type-I diabetes is managed with exogenous insulin and type-II with oral hypoglycemic agents (sulphonylureas, biguanides etc). In traditional practice medicinal plants are used in many countries to control diabetes mellitus. Alloxan, a drug which is widely used to induce experimental diabetes in animals and its mechanism of action in β cells of the pancreas has been intensively investigated. Th e cytotoxic action of this diabetogenic agent is mediated by reactive oxygen species and its product of reduction, the dialuric acid, establishes a redox cycle with the formation of superoxide radicals that undergo dismutation to hydrogen peroxide. Th e objective of this study is to investigate the histopathology of diabetes treated rats. Th e eff ect of methanolic extract (300 and 500 mg/kg body weight) of Erythrina indica stem bark on alloxan - induced diabetic rats was studied. Th e histopathological study was investigated in the liver, kidney and pancreatic tissue sections. Pathological lesions were evoked in diabetic rat cells. Th e extract improves the function of liver, kidney, pancreas and reduce the lesions associated with diabetic state in alloxan induced rats. Th e eff ect of oral administration of Erythrina indica at a dose of 500 mg/kg body weight was more effi cient than the 300 mg/kg body weight. Th e results indicate the protective eff ect of methanol extract on tissues and prove its potential as an antidiabetic agent.

Biography :

Arunjyothi.B pursuing Ph.D under Dr. Anupalli Roja Rani (Associate Professor), Department of Genetics, Osmania University, Hyderabad-500007, Andhra Pradesh, India.