alexa Immunogenicity And Protective Efficacy Of Oral Heat-killed Multi-serotype Shigella (HKMS) Vaccine In Rabbit Model | 9905
ISSN: 2157-7560

Journal of Vaccines & Vaccination
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

3rd International Conference on Vaccines & Vaccination
July 29-31, 2013 Embassy Suites Las Vegas, NV, USA

Dhrubajyoti Nag
Accepted Abstracts: J Vaccines Vaccin
DOI: 10.4172/2157-7560.S1.018
Abstract
B acillary dysentery caused by Shigella species, is a major cause of infant morbidity and mortality in developed as well as in developing countries. Now-a-days, we are approaching towards untreatable Shigellosis due to the global emergence of multidrug resistance which is increasing the importance of an anti-dysentery vaccine. Till date no suitable Shigella vaccine is available for public health use. The immune responses against Shigella species are serotype-specific and there are different serotypes of Shigella species which demands an immunization strategy that will include multiple vaccine strains to provide protection against multiple serotypes. In our study, we evaluated the protective efficacy and immune response of heat-killed cocktail form (HKMS) of six Shigella strains ( S. dysenteriae 1, S. flexneri 2a, S. flexneri 3a, S. flexneri 6, S. boydii and S. sonnei ) in rabbit model. Rabbits were immunized with 10 7 heat-killed Shigella strains four times with one week interval on 0, 7 th , 14 th & 21 st day and were challenged on the 28 th day with 10 9 organisms of wild type virulent Shigella strains. Immunized rabbits did not develop shigellosis compare to the non-immunized rabbits. Serum IgG and IgA titers showed exponential rise during oral immunization. Antibody in Lymphocyte Supernatant (ALS) assay, Cytokine assay and Immunoblotting against both whole cell lysates and lypopolysaccharide have demonstrated a strong protective immune response following the oral immunization of HKMS; thus justifying the potential of HKMS to become a ?non-living? vaccine candidate against shigellosis in our future.
Biography
Dhrubajyoti Nag has completed his graduation in Microbiology from University of Calcutta in 2009 and completed his post graduation in Biotechnology from Jadavpur University in 2011. Now he is doing his Ph.D. under the guidance of Dr. Hemanta Koley, Scientist C, National Institute of Cholera and Enteric Diseases, India, under a project of Okayama University, Japan, entitled Development and evaluation of a heat killed multi-serotype oral Shigella vaccine
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version