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|Krishna Valles S. L., Paredes-Brunet P., Aguirre-Rueda D. and Gil-Bisquert A.|
|Accepted Abstracts: Biochem Anal Biochem|
|The use of transgenic mice to elucidate Alzheimers disease has been development in the last decade. Here we use APP/ Preseniline 1 transgenic mice to analyse inflammation and oxidative stress in transgenic mice compared with wild type. Microarray from inflammation proteins, Western-blot and RT-PCR are used to compare wild type and transgenic mice. Increase in pro-inflammatory proteins and decrease in anti-inflammatory proteins were detected in transgenic compared with wild type. Also, using western-blot assay we detect an increase of NMDA R1 and a decrease of NMDA R2 in transgenic mice compared with wild type in hippocampus, limbic and cerebellum. In conclusion, an unbalance between inflammatory and anti-inflammatory proteins and also different regions in brain use different pathways to protect viability of cell brain against the toxicity in Alzheimers disease.|
Valles S. L. graduated in Biological Science at the University of Valencia in 1990 and remained there to undertake a Ph.D. under the supervision of Consuelo Guerri at Research Institution (Instituto de Investigaciones Citolgicas), which I completed in 1996. During my Ph.D. my dissertation was Changes of astroglia intermediate filaments gene expression during rat brain development: Effect of alcohol exposure. I analyze the events which occur during the early stages of astrogliogenesis during brain development, using in vivo and in vitro experiments. I did experiments in cells in culture primary as radial glia (stem cells in brain), astrocytes and neurons. In 1997 I joined Eva Qwanstroms group at the Hallamshire Hospital (University of Sheffiel) in Sheffield, UK and spent three years involved in the identification of an adhesion-regulated subunit of the interleukin-1 (IL-1) receptor complex. I was working in immunology, cytokines, inflammation processes and matrix regulation of IL-1 responses. In 2000 I returned to Spain at Department of Physiology, Medicine Faculty of Valencia. University of Valencia and I were appointed to a part-time position as Lectureship. In 2004 I was appointed to a fixed-term position as permanent University Lecturer at this department in the University of Valencia. During this time I was involved in the mechanisms of oxidative stress in the generation of Alzheimers disease with Jose Vias group. Also at this time I developed my lectures with Luis Suchs group with who I learned a lot about physiology and how to do a correct lecturer to pupils in my our department. At this moment I work in Alzheimers diseases and in inflammation and oxidative stress mechanisms. Also I would like to work in precursor cells and the subsequently ability to further differentiate into neurons and astroytes inside the brain. I order a grant from my sanity government and I still waiting for the resolution grant, about stem cells and brain.
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