alexa Kinesin-5 Mitotic Nano-motors: Directionality And Functions | 24388
ISSN: 2157-7439

Journal of Nanomedicine & Nanotechnology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

4th International Conference on Nanotek & Expo
December 01-03, 2014 DoubleTree by Hilton Hotel San Francisco Airport, USA

Leah Gheber
ScientificTracks Abstracts: J Nanomed Nanotechnol
DOI: 10.4172/2157-7439.S1.017
Abstract
The conserved kinesin-5 nano-motor proteins, which crosslink and move along microtubules, play essential roles in the mitotic spindle dynamics. We combine biophysical, cell biology and genetic approaches to study the activity of S. cerevisiae kinesin-5 motors, Cin8 and Kip1. We show that Cin8 and Kip1 are important for spindle elongation, midzone organization and interpolar microtubule plus-end dynamics during anaphase. We also show that Cin8 is differentially phosphorylated during anaphase at Cdk1 sites located in its motor domain. This phosphorylation is required for detachment of Cin8 from the spindle. Finally, we show that in vitro, Cin8 and Kip1 move towards the minus-ends of microtubules and can switch directionality. We thus examine the regulation of their directionality using single-molecule fluorescence motility assays and live-cell microscopy. Our data shed light on the mechanism of directionality control of the remarkable kinesin-5 motors.
Biography
Leah Gheber has completed his PhD at the age of 31 years from Ben-Gurion University and postdoctoral studies from Johns Hopkins University, Biology Department. Currently, she is an Assistant Professor at the Chemistry Department Ben-Gurion Universality, PI of the molecular nano-motors group and a head of the Teaching Committee. She has published more than 28 papers in reputed journals and was awarded several prestigious grants.
image PDF   |   image HTML
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version