alexa Lung Cancer Epigenetics: Lessons From The Mouse Embryo To Develop Novel Approaches For Early Diagnosis And Therapy Of Lung Cancer
ISSN: 2153-0645

Journal of Pharmacogenomics & Pharmacoproteomics
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

2nd International Conference on Predictive, Preventive and Personalized Medicine & Molecular Diagnostics
November 03-05, 2014 Embassy Suites Las Vegas, USA

Guillermo Barreto
ScientificTracks Abstracts: J Pharmacogenomics Pharmacoproteomics
DOI: 10.4172/2153-0645.S1.002
Several genes that are relevant during embryonic lung development share a similar gene structure with two distinct promoters driving the expression of two different transcripts. Expression of both transcripts from the same gene is complementary and is differentially regulated during embryonic development, with one transcript been expressed during early stages of lung development (embryonic isoform) and the other transcript been expressed at later stages and in adult lung (adult isoform). Interestingly, the embryonic isoforms are enriched in lung tumors of mice as well as of human, making them good candidates for lung cancer diagnosis. In addition, forced expression of the embryonic isoforms in murine adult lung is sufficient to induce hyperplasia with characteristic of lung adenocarcinoma supporting their oncogenic potential. Moreover, we found that the complementary expression of both isoforms from the same gene is mediated by differential promoter usage that is regulated by mechanisms that involve changes in the chromatin structure as specific histone modifications and dynamic DNA methylation. In conclusion, we suggest that an embryonic specific phenotype is acquired during lung cancer progression and this can be used for early diagnosis of lung tumors. In addition, approaches to suppress embryonic specific isoforms can be exploited to develop therapeutic strategies against lung cancer.
Guillermo Barreto is leader of the LOEWE Research Group Lung Cancer Epigenetic at the MPI for Heart and Lung Research and Faculty Member of the University of Giessen Lung Center (UGLC) and the Excellence Cluster Cardio-Pulmonary System (ECCPS). His research activities are centered on the epigenetic mechanisms that regulate the determination of the respiratory cell fate in the primitive foregut, leading to the formation of the lung bud and later on to the cellular diversity generated in the developing lung, with particular focus on those mechanisms that are recapitulated in several lung diseases.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version