In case of oral absorption of drug it dissolves first and then it gets absorbed by diffusion
through gastrointestinal (GI) membranes. Basically GI environment is aqueous in
nature and as well-known one third of drug population are water insoluble. Hence there
is need for solubility and dissolution of such drugs. In present research work solubility
and dissolution enhancement of practically insoluble drug Ibuprofen was done by
formation of bionanocomposites (BNC?s) using microwave induced diffusion (MIND),
which ultimately leads to bioavailability enhancement. The BNC?s were formed by using
natural polymers such as gelatin, acacia, cassia and ghatti gum with the help of microwave.
Selection of polymers was done on the basis of their surfactant and wetting property.
Solubility studies were done in order to establish solubility enhancing property of this
BNC?s. To support solubility analysis results, dissolution studies i.e. powder dissolution
and in vitro dissolution were done. It was found that as concentration of polymer in
composite increases the solubility and dissolution enhances. The optimized ratio (drug:
polymer) for all the composites was found to be 1:9. The BNC?s were characterized by
Fourier Transform Infra Red (FT-IR), differential scanning calorimetry (DSC), X-ray
diffraction studies (XRD) and Scanning Electron Microscopy (SEM). The results of
solubility and dissolution were confirmed by in vivo studies. In vivo performance of
optimized formulation was accessed by rat paw edema using male albino Wister rats and
demonstrated a significant reduction in inflammation when compared with marketed
formulation BRUFEN. The novelty of present work is green and cost effective way of
formation of drug nanocomposites with the help of microwave which can be scaled
at industrial level. The method gives perfect way of solublization by generating drug
dispersion at micro and nanoscale level in natural biodegradable stabilizing media.
Hence the present study demonstrates the use of BNC?s in solubility and dissolution
Mr. Sachin Shivaji Kushare has completed his M. Pharm. from North Maharashtra university Jalagaon.
He is Assistant Professor in R. G. Sapkal College of Pharmacy, Anjaneri, Nashik, A distinguished
institute in pharmaceutical education. He has two international publications with impact factor 2 in his
credit. He has attended 3 international, 10 national conferences and 2 workshops
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