Journal of Bacteriology & Parasitology

Multi resistant Elizabethkingia meningoseptica infections in tertiary care

3^rd International Congress on Bacteriology and Infectious Diseases

August 04-06, 2015 Valencia, Spain

Inam Danish Khan

Posters-Accepted Abstracts: J Bacteriol Parasitol

Abstract:

Background: Elizabethkingia meningoseptica is a ubiquitous Gram negative bacterium which is paradoxically susceptible to
anti-bacterial’s for Gram positive bacteria. Though found in diverse environments, it does not constitute human microflora
and is an emerging multi resistant pathogen known to cause a multitude of infections especially in immunodeficient hosts.
Results: Elizabethkingia meningoseptica was isolated from pleural fluid of a renal allograft recipient, continuous ambulatory
peritoneal dialysis fluid in a patient of chronic kidney disease and post-surgery blood cultures in salpingectomy and Mitral
valve replacement cases. Coexistent ESBL, AmpC and MBL along with resistance to polymyxins and tigecycline were observed.
Paradoxical susceptibility to sulfamethoxazole-trimethoprim (SXT) and cefoperazone-sulbactam facilitated treatment.
Discussion: Multi resistant Elizabethkingia infections are known to occur under aggressive Gram negative antimicrobial cover
and can be potentially untreatable. Alternative prolonged combination therapy with SXT, rifampicin, quinolones, piperacillintazobactam,
minocycline, macrolides, clindamycin and novobiocin is dependent on paradoxical susceptibility. Antimicrobial
susceptibility testing is difficult as these drugs are neither routinely considered for Gram negative organisms nor they are
available in automated system panels. Further, no CLSI guidelines exist for testing and interpretation. Dedicated efforts targeted
at early diagnosis and surveillance is required to optimize management and control of Elizabethkingia infections.