alexa Neurological Complications To Botulinum Toxin: A Therapy
ISSN: 2155-9597

Journal of Bacteriology & Parasitology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading
Loading Please wait..
 

International Congress on Bacteriology & Infectious Diseases
November 20-22, 2013 DoubleTree by Hilton Baltimore-BWI Airport, MD, USA

Anna Hristova
ScientificTracks Abstracts: J Bacteriol Parasitol
DOI: 10.4172/2155-9597.S1.002
Abstract
Botulinum type A therapy has been used worldwide for treatment of medical and cosmetic conditions. Due to its high potency there are no pharmacokinetic studies in humans. Little is known of how the toxin is processed in the central nervous system (CNS). For decades the safety of botulinum use has been based on the belief that the toxin stays confined to the injected site. However, there is a growing amount of evidence that the toxin can spread generally and cause significant clinical illness. The two most likely mechanisms of toxin inflicted damage are: interruption of the inter-neuronal communication on peripheral and central level and autoimmune reaction. My personal experience and the review of the literature suggest the following possible patterns of toxin induced damage: CNS: autoimmune encephalitis (3 cases of personal observation), likely centrally induced persistent fatigue and lack of endurance (5 cases of personal observation) and others (2 cases of personal observation); Peripheral nervous system: autoimmune reaction: Guillaine-Barre and small fiber polyneuropathy; Autonomic nervous system: heart arrhythmia (1 death: personal observation), constipation (2 cases of personal observation) and others. At present, there are no available tools for toxin isolation from the system, even in victims who died with botulism or in animals sacrificed to the toxin, since it disappears from the blood stream in the first 20 minutes, when injected in animals. Unless synaptosomal associated protein (SNAP 25) cleavage studies are conducted in specific organ tissues, there is little today to prove the causality of death or damage to the toxin.
Biography
Anna Hristova, M.D., has completed her medical education and board certification in Neurology in Europe and in USA. She finished two fellowships in movement disorders one of which at Columbia University, NY and an additional fellowship in Clinical Electrophysiology at Einstein University, NY. She received extensive training on botulinum toxin clinical use at Columbia University, NY and in Asia. She started using the toxin for treatment of medical cases in 1993. Her clinical research for the last 6 years has been focused on the side effects of botulinum toxin therapy. She has 25 years of clinical experience.
image PDF   |   image HTML
 

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords