alexa Nigral Mesenchymal Stem Cell Graft And/or GDNF Gene Transfer Promotes Functional Recovery In Hemiparkinsonian Rats
ISSN: 2157-7633

Journal of Stem Cell Research & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Share This Page

Additional Info

Loading Please wait..

3rd International Conference and Exhibition on Cell & Gene Therapy
October 27-29, 2014 Embassy Suites Las Vegas, USA

May-Jywan Tsai, Kang-Du Liu, Su-Fen Fan, Dann-Ying Liou, Ching-Feng Weng, Shih-Chieh Hung and Henrich Cheng
Posters: J Stem Cell Res Ther
DOI: 10.4172/2157-7633.S1.008
Parkinson?s disease (PD) is a neurological disorder characterized by the progressive loss of midbrain dopamine (DA) neurons. GDNF is known to exert neuroprotective and trophic effects on DA neurons. Bone marrow mesenchymal stem cells (MSC) represent potential cell sources for treating CNS injury. The present study aimed to evaluate the efficacy of nigral graft of human MSC and/or adenoviral (Ad) GDNF gene transfer in 6-OHDA-lesioned hemiparkinsonian rats. We used the immortalized human MSCs that retain their potential for neuronal differentiation. Pre-induced hMSC and/or Ad-GDNF were infused to the rat substantia nigra at 2 weeks after middle forebrain bundle infusion of 6-OHDA. Hemiparkinsonian rats receiving grafts of pre-induced hMSC or Ad-GDNF showed significant recovery in apomorphine- induced rotational behavior as well as numbers of nigral DA neurons. The result suggests that hMSC and GDNF have great potential in clinical cell therapy in Parkinsonian patients.
image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version