Journal of Vaccines & Vaccination

Novel strategy for oral vaccine against pathogens

International Conference & Exhibition on Vaccines & Vaccination

22-24 Nov 2011 Philadelphia Airport Marriott, USA

Mansour Mohamadzadeh

Scientific Tracks Abstracts: J Vaccines Vaccin

Abstract:

Effi cient oral vaccines potentiate mucosal and systemic innate imm une cells, antibody avidity and increase T cell longevity, partic ularly in immune compromised individuals. An eff ective and tolerable oral vaccine should ideally be given in one or more doses that can induce protective immunity against pathogenic microbes. Such an oral vaccine should be safe and cost eff ective. Data show that such a vaccine strategy can be achieved if it is targeted and directed to intestinal dendritic cells (DCs) th at induce mucosal and systemic immune responses against microbial or cancer challenge. A new generation of vaccine is being developed using small peptides derived from a phage display peptide library that target microbial antigens and expressed by Lactobacillus species, including L. gasseri . Data clearly show that the expression of anthrax protective antigen (PA), Flu-vaccine subunits or tumor associated antigens (rat new, legumain, _-catenin), genetically fused to dendritic cell binding peptide (DCpep) and expressed by L. gasseri confers robust humoral and T cell mediated immune protection against pathogens or cancer challenge in mice. To further improve the effi cacy of such an oral vaccine we are in the process to express it as a immunogenic fusion in L. gasseri by bacterial chromosomal insertion avoiding potential plasmid instability. By a double crossover recombination event, the genetic expression of the vaccine should be stabilized e liminating antibiotic selection. In this context, we currently investigate the genetic of such a vaccine expression and its effi cacy and impact on the survival of mice when infect by pathogens.

Biography :

Mansour Mohamadzadeh has completed his Ph.D at Johannes Gutenberg University in Mainz, Germany and postdoctoral studies from Johannes Gutenberg, and SWMU University School of Medicine. He is Department of Infectious diseases & pathology professor of Medicine at University of Florida Gainesvilla,Florida. He has published more than 60 papers in reputed journals. He is one of the leaders in vaccine and therapeutic strategies