Reach Us +1-504-608-2390
Serum IgE Induced Airway Smooth Muscle Cell Remodeling Is Independent Of Allergens And Is Prevented By Omalizumab | 52141
ISSN: 2155-6121

Journal of Allergy & Therapy
Open Access

Like us on:

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

7th International Conference on Allergy, Asthma and Clinical Immunology

Micheal Roth
University Hospital Basel, Switzerland
ScientificTracks Abstracts: J Allergy Ther
DOI: 10.4172/2155-6121.C1.002
Background: Airway wall remodeling is a major pathology of allergic asthma and is independent of inflammation. This pathology can be induced by purified human IgE, without the presence of allergens by activating airway smooth muscle cells (ASMC) to proliferation and depose extracellular matrix. Objective: We assessed if circulating IgE obtained from allergic asthma patients in the absence of allergens stimulates ASMC remodeling and if this can be prevented by anti-IgE antibodies. Methods: In vitro, human ASMC were exposed to serum of either healthy controls, or patients with allergic asthma, non-allergic asthma, or atopic non-asthma patients. Proliferation and deposition of collagens and fibronectin were determined after 3 and 5 days. Results: Serum from patients with allergies significantly stimulated ASMC proliferation at 3 and 5 days, the deposition of collagen type-I within 48 hours and of fibronectin within 24 hours. One hour pre-incubation of sera with omalizumab prevented these effects in allergic serum. In contrast, the anti-IgE antibody had no significant effect on serum from healthy donors or patients with nonallergic asthma. Furthermore, these effects were not modified by the presence of allergens. Conclusion: The data provides experimental evidence that anti-IgE antibodies neutralize the pro-remodeling activity suggesting that IgE is a major contributor ASMC mediated airway wall remodeling in asthma.

Michael Roth is currently working as the Head of Pulmonary Cell Research, Pneumology, University Hospital Basel, Switzerland. He has completed his PhD from University of Basel. He has worked as a Visiting Professor and Associate Professor for University of Sydney for 2 years. He has published 148 articles in reputed journals.

Email: [email protected]

image PDF   |   image HTML

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Business & Management Journals


[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version