alexa Surrogate Markers Of Occupational And Environmental Stressors, Functional Physiological Changes And Altered Pharmacokinetics In Healthy Indian Subjects | 23026
ISSN: 2329-6887

Journal of Pharmacovigilance
Open Access

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3rd International Conference and Exhibition on Pharmacovigilance & Clinical Trials
October 27-29, 2014 Hyderabad International Convention Centre, India

Jose S P, Thomas A, Samanta M K, Dubey S K and Arun K P
Posters: J Pharmacovigilance
DOI: 10.4172/2329-6887.S1.014
Abstract
Stress response, the interaction between individual and the living environment involve sympathetic arousal, release of catecholamine such as adrenaline, nor-adrenaline, cortisol and C-reactive proteins, Tumor Necrosis Factor α (TNF-α) as biomarkers of stress which affects functional physiological processes could lead to altered drug pharmacokinetic process inside body. The purpose of this study was to assess the intensity of occupational and environmental perceived stresses in healthy subjects living at various sites of Nilgiris district of Tamil Nadu and to check the psychometric properties, test retest validity and reliability by using the perceived stress scale 10, a self-reported, short and easy to use questionnaire established with acceptable psychometric properties to evaluate the degree to which individuals believe their life has been unpredictable, uncontrollable, and overloaded during the previous month. Among the 128 of study subjects, more number of subjects was found under the moderate and high category of perceived stress in both men and women participants. The mean age of high perceived category men was little major (43.42?10.30) than in extreme category (40.4?10.31) while women with moderate level and high perceived stress level were mean age of 42.33?09.06, 40.96 (11.57). The readability analysis such as Flesch Reading Ease Score and Gunning FOG score showed ideal acceptable ranges (70.2, 7.2) for fairly eases reading. The Cronbach?s Alpha value was 0.74, which has an excellent reproducibility. The test retest validity has also done in 20 subjects (>15% of the test population) after 14 days; in which the retest values were in the permitted limits.
Biography
Jose S P is a Research Scholar of JSS College of Pharmacy, JSS University, Ooty, Tamil Nadu from the year of 2014. He is qualified with MPharm (Clinical Pharmacy Practice-Dr. M. G. R. Medical University), MBA (Clinical Pharmacology) and has been working in the field of Clinical Pharmacology and Clinical Research since 2010. In career, he had worked with Amrita Institute of Medical Sciences, Apollo Hospitals Group Ltd. He is currently doing his Doctoral Research in the area of pharmacogenetics- pharmacokinetic dose optimization models in human population.
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