alexa Synthesis Of New Coumaryl-3-carboxamide Derivatives
ISSN: 2329-6798

Modern Chemistry & Applications
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International Conference on Applied Chemistry
October 17-18, 2016 Houston, USA

Mustafa Kucukislamoglu, Belma Zengin Kurt and Fatih Sonmez
Sakarya University, Turkey
Bezmialem Vakif University, Turkey
Posters & Accepted Abstracts: Mod Chem appl
DOI: 10.4172/2329-6798.C1.003
Abstract
The synthesis, reactions and biological properties of substituted coumarins constitute a significant part of modern heterocyclic chemistry. Compounds containing a coumarin moiety display a broad spectrum of biological activities such as antimicrobial, antifungal, anticoagulant, anti-HIV and insecticidal properties. Coumarins are an important class of CAIs for several reasons: (i) they were the first CAIs showing a high selectivity for inhibiting CA isoforms of interest for pharmacologic applications, such as the tumor-associated ones (hCA IX and XII, which are targets for antitumor/ anti-metastatic drugs) or the mitochondrial ones (CA VA and VB, which are targets for anti-obesity agents). 20 thiourea bearing coumaryl-3-carboxamid compounds were synthesized for the investigation of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) activities.
Biography

Mustafa Kucukislamoglu has completed his PhD from Karadeniz Technical University. He has been working at the Sakarya University, Chemistry Department as an academic staff since 1999. He has attended more than 30 national and international conferences. He has published more than 40 papers in reputed journals and his publications have been cited more than 350.

Email: [email protected]

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