The technical advance of radiotherapy enabled us to optimize the radiation fi
the tumor at our will. If the capsule that release anticancer medicine by radiation
can be innovated, the optimized radiation fi
eld will localize the anticancer medicine
to the tumor. In addition if the released anticancer drugs have synergistic eff
with radiation, increased anticancer eff
ect will be brought about via synergism with
anticancer medicine and radiation, and adverse eff
ect of anticancer medicine will be
decreased by its localization.
Since 2005, we have been developing microcapsules that release anticancer drugs
during radiotherapy and anticancer drug targeting. Th
e capsules were generated by
spraying a mixture of 3.0% hyaluronic acid and 2.0% alginate, supplemented with
, 0.2 mmol of carboplatin, and 0.5 mol/l FeCl
. Using these
microcapsules, two types of anticancer drug targeting were tested.
e microcapsules are subcutaneously injected in the area surrounding
the tumor, followed by delivery of radiations. Th
e irradiated microcapsules release
anticancer drug (carboplatin).
rst radiation was given to the area where we want to deliver drugs.
rs radiation induce P-selectin antigen. Th
e capsules that are labeled with
FcSV antibody of P-selectin are gathered by radiation-antigen (P-selectin) guided
e accumulated microcapsules were irradiated by second radiation
and release anticancer drug (carboplatin).
ese two types of microcapsules targeted the anticancer drugs.
e targeted anticancer drugs (carboplatin) along with radiation synergistically
acted against the tumor, resulting in increased antitumor activity. Localization of
anticancer drugs by using microcapsules decreased the adverse eff
ects of anticancer
Satoshi Harada got Japanese MD license at age of 25 and completed Phd at the age of 29
from postdoctoral studies from Iwate Medical University, School of Medicine. He is a assistant
professor of Iwate Medical University, School of Medicine, Department of Radiology. He wrote
more than 25 papers.
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