alexa Abstract | Acid Base Disorders in Critically Ill Neonatal Intensive Care Patients and Predicting Survival by the Presence of Deranged Acid-Base Variables
ISSN: 2167-0897

Journal of Neonatal Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article Open Access

Abstract

Objective: The acid base abnormalities are common in neonates with birth asphyxia and sepsis leading to considerable morbidity and mortality and timely assessment and management of these acid-base derangements leads to a better outcome. So, we did a observational study to assess acid base disorders in neonates by using Boston, Copenhagen approach and Stewart approach and the role of the various variables on predicting the acid base status and the worst outcome in neonates.
Study design and methods: An observational study was conducted on the samples provided from the neonates with birth asphyxia and sepsis admitted to neonatal intensive care unit (NICU) in the Post Graduate Institute of Medical Education and Research (PGIMER) and Dr Ram Manohar Lohia (Dr RML) Hospital, New Delhi, India. The blood gas analysis, electrolytes, albumin, lactate levels were compared in the two ailments. The presence of acid base disorders were calculated using Copenhagen approach and Stewart method; and the influence of various variables on acid base disorders and outcome were analyzed.
Results: The metabolic acidosis and alkalosis were seen in 1 and 10 patients as per Boston approach and in 18 and 18 patients with Copenhagen approach. The increased anion gap (AG), and low and high strong ion difference (SID) as measured by Stewart approach were seen in 23,21 and 23 neonates respectively. The acid-base status determined by both Copenhagen and Stewart approach were found to be interrelated. For detecting metabolic acidosis the sensitivity of high for high anion gap (66.67%) and hyponatremia (57.89 %) , whereas the specificity is high for lactic acidosis (94.74 %), hyperchloraemia (86.99%) and hyponatremia (81.08%). The low PaCO2 (89.4%) and low SID (73.68%) has a high sensitivity for predicting the non-survival , whereas the lactic acidosis(94.74%) has the high specificity of predicting the non-survival , followed by hyponatremia (81.08%), low SID (75.68%), hypoalbuminaemia (70.27%) and low PaCO2 (70.27%).
Conclusion: In neonates with birth asphyxia and sepsis, acid-base disorders are common. Both the approaches are good in determining the acid-base status, but in complicated situation strong ion difference and strong ion gap works better in determining acid-base status. Derangements like low PaCO2, low SID, hypoalbuminaemia, lactic acidosis and hyponatremia are predictors of worst outcome.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Imteyaz Ahmad, Arif Ahmed and Smita Roy

Keywords

Metabolic acidosis, Metabolic alkalosis, Base excess, Strong ion difference, Anion gap, Neonatal Jaundice, Respiratory Distress Syndrome, Breast Feeding, Umbilical cord

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

agrifoodaquavet@omicsonline.com

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

clinical_biochem@omicsonline.com

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

business@omicsonline.com

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

chemicaleng_chemistry@omicsonline.com

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

environmentalsci@omicsonline.com

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

engineering@omicsonline.com

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

generalsci_healthcare@omicsonline.com

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

genetics_molbio@omicsonline.com

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

immuno_microbio@omicsonline.com

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

omics@omicsonline.com

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

materialsci@omicsonline.com

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

mathematics_physics@omicsonline.com

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

medical@omicsonline.com

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

neuro_psychology@omicsonline.com

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

pharma@omicsonline.com

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

social_politicalsci@omicsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords