alexa Abstract | Triple Effect of Nonsense-Mediated mRNA Decay Inhibition as a Therapeutic Approach for Cancer
ISSN: 2168-9431

Single Cell Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Perspective Article Open Access

Abstract

Cancer is a complex pathology involving different genes and cellular pathways. A combination of treatments with different targets is thus required to eliminate cancer cells. This review deals with a new potential therapeutic approach: inhibiting a single RNA degradation pathway so as to inhibit tumorigenesis by acting on different cellular processes and on the expression of various genes. Also discussed is the re-expression of various genes: tumor suppressor genes harboring a nonsense mutation, NMD-silenced oncogenes, and genes inducing a specific anticancer immune response. Lastly, putative limitations of cancer treatment by NMD inhibition are addressed.

To read the full article Peer-reviewed Article PDF image | Peer-reviewed Full Article image

Author(s): Fabrice Lejeune

Keywords

Cancer, Nonsense-mediated mRNA decay, Premature termination codon, Tumor suppressor, Immunotherapy, Single Cell Analysis,Single cells,Liver cancer

Share This Page

Additional Info

Loading
Loading Please wait..
 
 
 
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords