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Gene Technology
Gene profiling
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Gene profiling
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Gene profiling Share this page 
Gene profiling is the measurement of the activity of thousands of genes at time or to create a complete picture of cellular function. Gene expression profiling is the determination of the pattern of genes expressed, at the level of transcription, under specific circumstances or in a specific cell to give a global picture of cellular function. In almost all cells in an organism contain the entire genome of the organism only a small subset of those genes is expressed as messenger RNA (mRNA) at any given time and their relative expression can be evaluated. Techniques which are involved in profiling include DNA microarray technology or sequenced-based techniques such as serial analysis of gene expression.
Related Journals of Gene Profiling
Gene Technology, Human Genetics & Embryology, Journal of Genetic Syndromes & Gene Therapy, Hereditary Genetics: Current Research, Genes Chromosomes and Cancer, Genes to Cells, Genesis, Genes and Immunity, Genetic Epidemiology, PLoS Genetics.
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Classically, the 3âuntranslated region (3âUTR) is that region in eukaryotic protein-coding genes from the translation termination codon to the polyA signal. It is transcribed as an integral part of the mRNA encoded by the gene. However, there exists another kind of RNA, which consists of the 3âUTR alone, without all other elements in mRNA such as 5âUTR and coding region. The importance of independent 3âUTR RNA (referred as I3âUTR) was prompted by results of artificially introducing such RNA species into malignant mammalian cells. Since 1991, we found that the middle part of the 3âUTR of the human nuclear factor for interleukin-6 (NF-IL6) or C/EBP gene exerted tumor suppression effect in vivo. Our subsequent studies showed that transfection of C/EBP 3âUTR led to down-regulation of several genes favorable for malignancy and to up-regulation of some genes favorable for phenotypic reversion. Also, it was shown that the sequences near the termini of the C/EBP 3âUTR were important for its tumor suppression activity. Then, the C/EBP 3âUTR was found to directly inhibit the phosphorylation activity of protein kinase CPKC in SMMC-7721, a hepatocarcinoma cell line. Recently, an AU-rich region in the C/EBP 3âUTR was found also to be responsible for its tumor suppression. Recently we have also found evidence that the independent C/EBP 3âUTR RNA is actually exists in human tissues, such as fetal liver and heart, pregnant uterus, senescent fibroblasts etc. Through 1990âs to 2000âs, world scientists found several 3âUTR RNAs that functioned as artificial independent RNAs in cancer cells and resulted in tumor suppression. Interestingly, majority of genes for these RNAs have promoter-like structures in their 3âUTR regions, although the existence of their transcribed products as independent 3âUTR RNAs is still to be confirmed. Our studies indicate that the independent 3âUTR RNA is a novel non-coding RNA species whose function should be the regulation not of the expression of their original mRNA, but of some essential life activities of the cell as a whole.
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Nucleotide variations in exon 2 of leptin gene (LEP) in sheep breeds of Tamil Nadu
PPT Version | PDF Version - Alireza Hadj Khodabakhshi
Organization and analysis of large scale mutation datasets produced by next generation sequencing technologies
PPT Version | PDF Version - Pavel Tarlykov
Pharmacogenetic kit for individual correction of Warfarin and Clopidogrel dosage in central Asian population
PPT Version | PDF Version - Daniel Rotroff
Using DNA copy number aberrations in naturally occurring canine cancers to identify candidate drivers of carcinogenesis
PPT Version | PDF Version - Nisreen E. Mahmoud
Parasitological and comparative pathological studies on monogenean infestation of cultured sea bream (Sparus aurata, Sparidae) in Egypt.
PPT Version | PDF Version - Chuanling Zhang
Genetic Code Expansion in Natural Propagation for Site-Specific Engineering and Tracking of Single Adeno-Associated Viruses
PPT Version | PDF Version - Iqbal Parwez
Genetic diversity and molecular declining population of four Channid species from North India and possible strategies
PPT Version | PDF Version - Matjaz Sajovic
Knee objective stability and isokinetic thigh muscle strength after anterior cruciate ligament reconstruction: A randomized six-month follow-up study
PPT Version | PDF Version - Yajun Yi
Meta-analysis of transcriptional profiles in cancer for prognosis prediction and metastatic gene identification
PPT Version | PDF Version - Jun Li
A novel epigenetic mark, Histone H1 fucosylation, regulates macrophage plasticity in Rheumatoid arthritis
PPT Version | PDF Version - Luminita Castillos
Gene expression profiling for targeted cancer treatment
PPT Version | PDF Version - Ruslan N. Grishanin
Adeno-associated virus-mediated delivery of amyloid β antibody for treatment of age-related retinal degenerative diseases
PPT Version | PDF Version - Murali Krishna P V
Walking theory- Human walking is analyzed using PET-CT analysis and theorized utilizing the published research papers: Movement of the body analyzed systematically
PPT Version | PDF Version - Juan B. Kouri Flores
Cytokines expression during OA pathogenesis within an experimental rat model
PPT Version | PDF Version - Asem Surindro Singh
Population and family based association study on TPH1, TPH2 and ITGB3 genes indicate serotonergic system involvement in autism spectrum disorder
PPT Version | PDF Version - Jung-Joon Min
Bacteria-mediated expression of cargo drugs and reporter gene for cancer-specific theranostics
| PDF Version - Attila Lawrence
A Theoretical Framework for Environmental Design Interventions to Support Neurodegenerative Disease Management
PPT Version | PDF Version - Maria Celia Jamur
The role of mast cell proteases in tumor angiogenesis
PPT Version | PDF Version - Jeffrey Zheng
Pseudo DNA Sequence Generation of Non-coding Distributions using Stream Cipher Mechanism
PPT Version | PDF Version - Moritz C. Oberstadt
Epigenetics in glioma
PPT Version | PDF Version - Daniela Del Gaudio
The Importance of Making a Genetic Diagnosis in Monogenic Forms of Diabetes
PPT Version | PDF Version - Irina Perepechina
Development of the standard of the determination of genetic identity on the basis of the predetermined level of reliability of DNA identification
PPT Version | PDF Version - Elfahmi
The role of p19 gene in the transformation efficiency of amorphadiene synthase in Artemisia annua for artemisinin production
PPT Version | PDF Version - Paul H. Lerou
Exploring human pluritotent stem cell heterogeneity using a multi-scale imaging and informatics pipeline
PPT Version | PDF Version - Nguyen Linh Toan
Molecular impacts of virus infections and genetic variants on the course of HBV-related liver diseases in Vietnam
PPT Version | PDF Version - Fuad Fares
Developing long acting agonists and antagonists of glycoprotein hormones using gene fusion and gene transfer: From bench to clinics
PPT Version | PDF Version - Abeer Kadry El Zohiery
Role of bone morphogenetic protein-2 in primary Knee osteoarthritis
PPT Version | PDF Version - Ghazala Rubi
Genetic Susceptibility of HCV RNA and its genotypic distribution in the Punjab, Pakistan
PPT Version | PDF Version - Paul L. Hermonat
The new genetics of adeno-associated virus
PPT Version | PDF Version - Yaron Tikochinski
Conservation of Green Sea Turtles through Genetics and Genomics
PPT Version | PDF Version - Paul J. Davis
Nanotetrac targets the thyroid hormone receptor on integrin αvβ3 on tumor cells to promote apoptosis, disorder cell defense pathways and block angiogenesis
PPT Version | PDF Version - Charles C. Muscoplat
Itâs not your Grandmothers cookbook anymore: Chemicals and genes in your food; with the chemicals and genes in you!
PPT Version | PDF Version - Trevor R.F. Smith
Generation of robust immunity following DNA vaccine immunization enhanced by intradermal electroporation
PPT Version | PDF Version - Alison Burton Shepherd
Can we really trust genetically modified foods?
PPT Version | PDF Version - Alexander V. Sirotkin
New hormonal and intracellular regulators of reproduction
PPT Version | PDF Version - Juliette Mangeney
Juliette Mangeney
PPT Version | PDF Version - Amparo Pascual-Ahuir Giner
Real time analysis of gene expression in living yeast cells: Novel approach for accurate cell damage detection
PPT Version | PDF Version - Flavio Antonio de Sa Ribeiro
Inguinal hernia repair with local anesthesia in the outpatient, being safe, effective, easy to perform, yet having a lower cost
PPT Version | PDF Version - Maria Teresa Mascellino
Candida bloodstream infections: species distribution and antifungal resistance in General Medicine wards and in Intensive Care Units (ICUs)
PPT Version | PDF Version - Jian Jun Wei
MicroRNAs and the target genes in early tumorigenesis of fallopian/ovarian carcinoma
PPT Version | PDF Version
