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World Biotechnology 2016
August 15-17, 2016
Volume 6 Issue 5(Suppl) J Biotechnol Biomater 2016
ISSN: 2155-952X JBTBM, an open access journal
conferenceseries .com
August 15-17, 2016 Sao Paulo, Brazil
Biotechnology World Convention
Modeling ER stress and associated disorders on the onset of obesity
Rajat Kumar De and Indrani Ray
Indian Statistical Institute, India
Obesity is an epidemic of the 21st century. It continues to expand inwestern countries and paradoxically even in the countries
where poverty and malnutrition are major problems. No age group is exempted from obesity due to different reasons, i.e.,
diet, life style and genetic component among others. In this talk we describe how a computational model can be formulated to
understand the mechanism of the development of ER stress and associated disorders on the onset of obesity. For this purpose,
we collected extensively ER and ER stress related pathways information to construct a set of global pathways by including other
related pathways, like apoptosis, diabetes, inflammation, protein degradation and obesity. With all these pathway database and
literature, we design an integrated pathway, through mining strategies, to form a biochemical pathway related to ER stress and
obesity. We find out the control points regulating the activity (i.e., ON or OFF through feedback inhibition) of the integrated
pathway. We also find out the genes coding for the enzymes catalyzing the reactions in the pathway. The talk will also describe
design of a database containing all this information. The pathways in the database will then be subjected to network analysis.
We use flux balance analysis, control theory and machine learning methodology to develop the model of the pathway as well
as to analyze the pathways/networks. The properties of the pathways/networks are very important from therapeutic point of
view, as in simple terms, they have the power to control the whole system.
Biography
Rajat Kumar De is a Professor of Indian Statistical Institute, India. He has obtained his PhD degree from the same Institute in 2000. He was a Distinguished
Postdoctoral Fellow at the Whitaker Biomedical Engineering Institute, Johns Hopkins University, USA, during 2002-2003. During the last 10-12 years, he has
been working in the area of bioinformatics and in silico systems biology. Recently, he has started working on Big Data Analytics in the domain of bioinformatics
and systems biology. He has published about 85 research papers in international journals, conference proceedings and edited books and co-edited two books.
Rajat Kumar De et al., J Biotechnol Biomater 2016, 6:5(Suppl)