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Volume 4, Issue 5(Suppl)

J Infect Dis Ther

ISSN: 2332-0877 JIDT, an open access journal

Euro Infectious Diseases 2016

September 05-06, 2016

Page 10

Notes:

conference

series

.com

Infectious Diseases

September 05-06, 2016 Frankfurt, Germany

3

rd

Euro-Global Conference on

Bunyaviruses and other emerging zoonotic RNA viruses

T

here is an expanding group of identified emerging zoonotic RNA viruses whose prevalence and sensitivity to anthropogenic

disruption epitomize the ongoing “third epidemiological transition” in human history, which is marked by emergence of

novel pathogens and re-emergence of previously identified infectious microbes. Examples of recent and ongoing outbreaks

initiated by these RNA viruses include hemorrhagic fever following infection by the filovirus, Ebola and fetal neuromal

formation arising from infection by the Flavivirus, Zika. The bunyaviruses comprise the largest group of RNA viruses and

include multiple emerging zoonotic species that are pathogenic in humans. This family of viruses has a genome composed of

three minus strand RNA segments. Using

Sin Nombre Hantavirus

and Rift Valley fever virus as models, we have been elucidating

multiple facets of bunyavirus biology including fundamental strategies of the virus for genome expression, replication and

packaging and we have been exploring key features of virus-host interaction. The replication of these viruses intersects with

cytoplasmic RNA metabolism pathways physically associated with processing bodies (PBs) and stress granules (SGs). This

association has important implications for mRNA synthesis and genome replication. Specific components of the

cytoplasmic

granules

are also important for efficient virus replication, playing a direct role in viral RNA function. Generation of a specific

mechanistic picture of how these cellular components function in virus replication will provide insight into the intricacies of

virus replication. These cellular components are also potential targets for broad-spectrum antivirals as these cellular co-factors

appear to be required for the replication of multiple diverse bunyaviruses.

Biography

Nito Panganiban is a Professor and Interim Division Chair of Microbiology at the Tulane National Primate Research Center, Chief Scientific Officer at Peptineo and

a Member of the Department of Microbiology and Immunology at the Tulane University School of Medicine. The focus of his academic research lab is centered on

diverse emerging RNA viruses with emphasis on pathogenic, zoonotic RNA viruses including members of the bunya and Flavivirus families including Zika virus, Rift

Valley Fever, Crimean Congo hemorrhagic fever and Hantaviruses.

[email protected]

Nito Panganiban

Tulane University, USA

Nito Panganiban, J Infect Dis Ther 2016, 4:5(Suppl)

http://dx.doi.org/10.4172/2332-0877.C1.010