Journal of Carcinogenesis & Mutagenesis

Alejandro Zentella-Dehesa

Publications

• Research Article
  MICA Regulates the Expression of DAP10 and Signals through an Independent PI3K Pathway in NKG2D Positive Cervical Cancer Cells
  Author(s): Isabel Soto-Cruz, Octavio Zerecero-Carreón, Francisco Trejo-Islas, José Luis Ventura-Gallegos, Alejandro Zentella-Dehesa, Benny Weiss-Steider and Jorge Flavio Mendoza-RincónIsabel Soto-Cruz, Octavio Zerecero-Carreón, Francisco Trejo-Islas, José Luis Ventura-Gallegos, Alejandro Zentella-Dehesa, Benny Weiss-Steider and Jorge Flavio Mendoza-Rincón
  
  NKG2D receptor engages ligands such as MICA and MICB, which activates cytotoxicity in NK cells leading to the destruction of tumour cells expressing these ligands. In normal human lymphoid cells the association of DAP10 with NKG2D is essential for signalling and important for its cell surface expression. However, the mechanism of the NKG2D/DAP10 complex upregulation is not completely understood in cancer. Also, the role of DAP10 in the activation of the PI3/AKT signaling pathway in cervical cancer has not been fully elucidated. In the present study, we investigated the role of MICA in the regulation of DAP10 in cervical cancer cells. First, we demonstrate the presence of the NKG2D/DAP10 complex in different tumour cell lines by flow cytometry. Also, we demonstrate that MICA upregulates the expression of DAP10 in cervical cancer cells in a time dependent manner by immunoblotting. We fo.. View More»
  DOI: 10.4172/2157-2518.1000329

  Abstract PDF