Journal of Vascular Medicine & Surgery

Dao P

Publications

• Research Article
  Impairment of Pulmonary Vasoreactivity in Response to Endothelin-1 In Patients With Chronic Obstructive Pulmonary Disease (COPD)
  Author(s): Duong-Quy S, Dao P, Hua-Huy T, Le-Dong NN and Dinh-Xuan ATDuong-Quy S, Dao P, Hua-Huy T, Le-Dong NN and Dinh-Xuan AT
  
  Background: Pulmonary hypertension secondary to COPD is characterized principally by impairment of vasoreactivity and vascular remodeling. While the structural changes have been described in all stages of COPD, the impairment of vasoreactivity in response to ET-1, a potent vasoconstrictor, has not been well understood. Materials and methods: Proximal pulmonary arteries were obtained from non-smokers, smokers with normal lung function, and COPD patients who underwent lung resection for other diseases (n=6 in each group). Pulmonary arterial contraction induced by ET-1 was assessed without or with the presence of ET-1 receptor antagonists (BQ- 123 and BQ-788). Expressions of ET-1 receptors were measured by immunohistochemistry, western blot, and qRTPCR. Results: ET-1-induced pulmonary arterial contraction increased signif.. View More»
  DOI: 10.4172/2329-6925.1000213

  Abstract PDF