Biology and Medicine

Ishola Azeez

Publications

• Research Article
  Defect in Synaptic Pruning of Motor Cortex Neurons is Associated with Early Perturbed Dopaminergic System
  Author(s): Bankole Oluwamolakun, Ogunnusi Tolulope, Laoye Babafemi, Ishola Azeez and Poluyi EdwardBankole Oluwamolakun, Ogunnusi Tolulope, Laoye Babafemi, Ishola Azeez and Poluyi Edward
  
  Background: Early stress exposure during neurodevelopmental stages has been linked to some adult neuropsychiatric disorders. The dopaminergic system which has been implicated in movement and reward system has been linked to movement and mood disorders when perturbed at early development. This study is designed to check the mechanisms involved in movement disorders such as dyskinesia, associated with early perturbed dopaminergic system in the motor cortex Methods: Haloperidol was used to block D2R in neonatal albino Wistar rats in utero by administering 20 mg/kg BW (intraperitoneally) to pregnant adult wistar rats (n=8) in the third week of gestation. Behavioural studies such as the rotarod test were carried out on the neonatal animals (n=5) to test their motor function at postnatal day twentyeight (P28). Electrophysiological recordings were .. View More»
  DOI: 10.4172/0974-8369.1000449

  Abstract PDF