Journal of Carcinogenesis & Mutagenesis

John Pierce Wise

Publications

• Research Article
  Chronic Exposure to Particulate Hexavalent Chromium Alters Cdc20 Protein Localization, Interactions and Expression
  Author(s): Naga D. Karri, Hong Xie and John Pierce WiseNaga D. Karri, Hong Xie and John Pierce Wise
  
  Hexavalent chromium [Cr(VI)] compounds are well established human lung carcinogens, but it is unknown how they cause lung cancer in humans. Recent data indicate that Cr(VI) induces chromosome instability in human lung cells, and genomic instability is considered a leading mechanism to explain chromate carcinogenesis. The Spindle Assembly Checkpoint (SAC) is a critical regulator of the metaphase-to-anaphase transition and ensures genome stability by preventing chromosomal missegregation events. Bypass of the SAC can lead to genomic instability, manifested as aneuploidy, which eventually leads to tumor formation and cancer. Recent studies in our laboratory demonstrated that chronic exposure to zinc chromate induces SAC bypass in a concentration- and time-dependent manner in human lung fibroblasts. To further study these events, we focused on the cell division cycle 20 (Cdc20) protein, a.. View More»
  DOI: 10.4172/2157-2518.1000140

  Abstract PDF