Journal of Liver

Shinohara MI

Publications

• Research Article
  Elevation of Serum Apolipoprotein B after Successful Eradication of Hepatitis C Virus in Patients with Chronic Hepatitis C Treated by IFNBased Therapy
  Author(s): Kogame M, Ishii K, Kanayama K, Shinohara MI and Sumino YKogame M, Ishii K, Kanayama K, Shinohara MI and Sumino Y
  
  Background: Hepatitis C Virus (HCV) infection is closely tied to the lipid metabolism of liver cells. We recently reported that serum levels of LDL- and VLDL-cholesterol (Cho) increased in patients with Chronic Hepatitis C (CHC) showing Sustained Virologic Response (SVR) after treatment with interferon (IFN)-based therapy. LDL- and VLDLCho contained apolipoprotein (apo)-B synthesized in the liver as a major protein component. The goal of the present study was to clarify how serum lipid markers change in CHC patients showing SVR after treatment with IFN-based therapy. Patients and methods: The study included 121 consecutive patients with CHC infected with HCV genotype 1 (n=66, male/female: 40/26) or HCV genotype 2 (n=55, male/female: 38/17). Ninety-five patients received PEGIFN alpha and Ribavirin (RBV). Twenty-six patients received PEG-IFN a.. View More»
  DOI: 10.4172/2167-0889.1000113

  Abstract PDF