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Volume 8, Issue 5 (Suppl)
J Addict Res Ther, an open access journal
ISSN: 2155-6105
6
th
World Congress on
August 29-31, 2017 | Prague, Czech Republic
Addiction Disorder & Addiction Therapy
Addiction Congress 2017
August 29-31, 2017
Transgenerational effect of adolescent male rat morphine exposure on pain perception and morphine
analgesia in the offspring
Narges Pachenari
Tarbiat Modares University, Iran
D
uring the past decades, use/misuse of opioids has dramatically increased among adolescent population. It is firmly confirmed that
different morphological and physiological changes occur in the brain during adolescence. Brain development and maturation,
during this critical period, could be affected by several factors, including stress, drug abuse, nutritional status, etc. While studies
on transgenerational effect of substances such as alcohol, nicotine and cocaine are focused on both paternal and maternal drug
exposure, most of the studies of morphine administration are restricted to maternal exposure. So in this study we aimed to investigate
transgenerational effect of male rats on morphine administration during adolescence against pain perception and morphine analgesia
in the offspring. Male rats received escalating doses of morphine for 10 days during their adolescence. 20 days after last morphine
injection, male rats were mated with intact female rats and then behavioral tests conducted on the offspring. Pain perception was
evaluated by formalin test, and morphine analgesia by formalin, tail flick and paw withdrawal tests. Our results demonstrated that
morphine and saline sired animals differ in interphase of formalin test. Besides, morphine sired animals respond more strongly to
acute morphine injection in comparison to saline sired ones. Overall, these findings indicate significant transgenerational effect of
morphine exposure during adolescence on pain perception and morphine analgesia in the offspring.
n.pachenari@yahoo.comNarges Pachenari, J Addict Res Ther 2017, 8:5 (Suppl)
DOI: 10.4172/2155-6105-C1-033