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Addiction Psychiatry 2018
Journal of Addiction Research & Therapy
ISSN: 2155-6105
Page 52
August 13-14, 2018
Madrid, Spain
8
th
International Conference on
Addiction Psychiatry
Background:
The problem of alcoholism perpetuates from
antiquity, it was from the eighteenth century that for the first time,
England identified the excessive consumption of alcohol as a
widespread problem of public health. Over the years this theme
has been well studied and can be observed the global impact it
generates in terms of care and financial. The pharmacological
options for the treatment of alcoholism are restricted, and
naltrexone, an opioid antagonist, is the most used, especially
in the case of severe addiction. However, not all patients
respond to treatment, which requires the investigation of new
therapeutic options. Ayahuasca is a psychoactive drink used in
rituals of indigenous tribes. This drink is prepared by the firing
of Banisteriopsis caapi stems, which contains β-carbolines that
are inhibitors of monoamine oxidase (MAO), an enzyme that
degrades the neurotransmitter serotonin (5HT), and leaves of
Psychotria viridis, which contains the N,N-dimethyltryptamine
(DMT) entheogen, a potent 5HT2A receptor agonist.
Objective:
The objective of this study evaluates the therapeutic
potential of ayahuasca in the treatment of alcohol dependence
in Wistar rats.
Methods:
For the execution of the experiment, the IA2BC protocol
(intermittent access to 2-bottle choice) was used to induce
alcoholism in the animals for seven weeks and then received
treatments for five days.
Results:
The IA2BC protocol was shown to induce a gradual
increase in voluntary alcohol intake, leaving the animals addicted.
Alcohol consumption by the animals showed that both the
naltrexone group and the 1X ayahuasca group had lower alcohol
consumption than the placebo H
2
O group.
Conclusion:
The decrease in alcohol consumption by treated
animals shows the efficiency of the drug naltrexone (positive
control) and ayahuasca 1X.
luciana_nolli@yahoo.com.brEvaluation of the therapeutic potential of ayahuasca in the
treatment of alcohol dependence in an experimental model
Luciana M Nolli
University of Brasília, Brazil
J Addict Res Ther 2018, Volume 9
DOI: 10.4172/2155-6105-C2-040