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series

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Volume 8, Issue 5 (Suppl)

J Biom Biostat, an open access journal

ISSN: 2155-6180

Biostatisitcs 2017

November 13-14, 2017

November 13-14, 2017 | Atlanta, USA

6

th

International Conference on

Biostatistics and Bioinformatics

Unbiased estimation after phase II clinical trials involving multiple endpoints

T

he single arm, two-stage clinical trial design is a popular methodology to evaluate oncology treatments in the phase II

setting. The designs are typically augmented with an ad hoc toxicity monitoring rule which is imposed outside of the

formal two-stage design but there are also several designs that formally incorporate both endpoints simultaneously. There are

many problems that prevent the designs from being used in practice which includes point estimation after the execution of

the study. We will examine an unbiased estimator that accounts for both endpoints simultaneously along with the correlation

between the endpoints. The behavior of the estimate is examined through simulation studies. It is compared to the maximum

likelihood estimator.

Biography

Herman Ray has received his PhD from the University of Louisville, where he has conducted research at the JG Brown Cancer Center. He currently has several

manuscripts published in clinical trial design and bioinformatics as well as STEM education policy in the secondary education system. He is now an Associate

Professor of Statistics at Kennesaw State University as well as the Director of the Center for Statistics and Analytical Research which is housed within the new

Analytics and Data Science Institute.

hray8@kennesaw.edu

Herman Ray

Kennesaw State University, USA

Herman Ray, J Biom Biostat 2017, 8:5 (Suppl)

DOI: 10.4172/2155-6180-C1-004